211571-70-9Relevant academic research and scientific papers
Synthesis of pluriaminated pyridines
De Munno, Angela,Bertini, Vincenzo,Picci, Nevio,Lemma, Francesca,Pocci, Marco
, p. 1203 - 1211 (1998)
The key reagent 3,5-dichloro-4-pyridinecarbonitrile (1) was used to synthesize 4-aminomethylpyridine derivatives 3,5-disubstituted with various amino groups, very active as inhibitors of diamine oxidase. The study of the reaction allowed to discover conditions for the gradual substitution in good yields of the two chlorine atoms to give symmetrically and unsymmetrically disubstituted derivatives (3), or the substitution of the cyano group, or the formation of amidines. The reduction of the cyano to aminomethyl group in compounds (3) afforded the target bioactive products.
Aminopyrimidine derivatives, processes for their preparation, compositions containing them and their use as pharmaceuticals
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, (2008/06/13)
There are provided novel compounds of formula (I) wherein: A represents a five membered heterocyclic aromatic ring containing 1 to 3 heteroatoms which may be the same or different and are selected from O, N and S; or a six membered heterocyclic aromatic r
