211613-37-5Relevant academic research and scientific papers
Towards Enzyme-like, Sustainable Catalysis: Switchable, Highly Efficient Asymmetric Synthesis of Enantiopure Biginelli Dihydropyrimidinones or Hexahydropyrimidinones
Lillo,Saá
supporting information, p. 17182 - 17186 (2016/11/23)
Organocatalysts displaying a network of cooperative hydrogen bonds (NCHB) have been employed in an enzyme-like manner for a direct, switchable synthesis of enantiopure hexahydropyrimidinones (HHPMs) or dihydropyrimidinones (DHPMs), which starts at a common, easily accessible α-ureidosulfone stage. The NCHB organocatalyst exploits all its potential as a pure hydrogen-bond biomimetic catalyst even in the presence of organic bases. This one-pot, diastereo- and enantioselective synthetic procedure has been proven to be robust, scalable, highly efficient, and environmentally benign. A straightforward and truly practical entry to enantiopure HHPMs is reported for the first time.
Cooperative and enantioselective NbCl5/primary amine catalyzed Biginelli reaction
Cai, Yong-Feng,Yang, Hua-Meng,Li, Li,Jiang, Ke-Zhi,Lai, Guo-Qiao,Jiang, Jian-Xiong,Xu, Li-Wen
experimental part, p. 4986 - 4990 (2010/11/03)
A series of chiral organocatalysts and Lewis acids have been evaluated in the Lewis acid/organocatalysts-based cooperative catalytic Biginelli reaction, which resulted in the determination of a novel cooperative Lewis acid/primary amine catalyst system, N
