211617-68-4

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 288-32-4 1H-imidazole 

Downstream Products

• 643090-88-4 N-Boc-D-Phe-ΔTyr(OTIPS)-OMe 
• 868164-50-5 1-[4-(triisopropylsilanyloxy)-phenyl]-but-3-en-1-ol 
• 137837-67-3 triisopropyl(4-vinylphenoxy)silane 
• 1163689-92-6 4-((triisopropylsilyl)oxy)benzoic acid 
• 643090-87-3 N-Boc-D-Phe-V-ΔTyr(OTIPS)-OMe 
• 643090-94-2 N-Boc-D-Phe-ΔTyr(OTIPS)-CH2OH 
• 854423-37-3 methyl (2'E,6'E,10'E)-2-[1'-13C]geranylgeranyl-4-(triisopropylsilyloxy)benzoate 
• 854423-11-3 methyl 2-iodo-4-(triisopropylsilyloxy)benzoate 
• 854423-41-9 2-iodo-4-triisopropylsilanyloxy-benzoic acid 

Relevant academic research and scientific papers

Fluorescent probe for fluorine ion detection, application of fluorescent probe and method for detecting fluorine ions in to-be-detected sample

The invention belongs to the technical field of analytical chemistry, and particularly relates to a fluorescent probe for fluorine ion detection, application of the fluorescent probe and a method for detecting fluorine ions in a to-be-detected sample. The invention provides a compound as shown in a formula I, or an optical isomer or salt thereof, and provides application of the compound as a fluorine ion detection fluorescent probe. According to the method for detecting the fluorine ions in the to-be-detected sample, the compound, or the optical isomer or the salt of the compound is used as a fluorine ion detection fluorescent probe for detection. The fluorescent probe has the advantages of good water solubility, high selectivity, high response speed, low detection limit, good stability, wide applicable pH range and good application prospect.

An Electroreductive Approach to Radical Silylation via the Activation of Strong Si-Cl Bond

The construction of C(sp3)-Si bonds is important in synthetic, medicinal, and materials chemistry. In this context, reactions mediated by silyl radicals have become increasingly attractive but methods for accessing these intermediates remain limited. We present a new strategy for silyl radical generation via electroreduction of readily available chlorosilanes. At highly biased potentials, electrochemistry grants access to silyl radicals through energetically uphill reductive cleavage of strong Si-Cl bonds. This strategy proved to be general in various alkene silylation reactions including disilylation, hydrosilylation, and allylic silylation under simple and transition-metal-free conditions.

Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes

An asymmetric intermolecular, three-component radical-initiated dicarbofunctionalization of 1,1-diarylalkenes with diverse carbon-centered radical precursors and electron-rich heteroaromatics by a copper(I) and chiral phosphoric acid cooperative catalysis strategy has been developed, providing straightforward access to chiral triarylmethanes bearing quaternary all-carbon stereocenters with high efficiency as well as excellent chemo- and enantioselectivity. The key to success is not only the introduction of a sterically demanding chiral phosphoric acid to favor radical difunctionalization over the otherwise remarkable side reactions but also the in situ generation of carbocation intermediates from benzylic radical to realize asymmetric induction with the aid of a removable hydroxy directing group via cooperative interactions with chiral phosphate. Density functional theory calculations elucidated the critical chiral environment created by the hydrogen-bonding and ion-pair interactions between the chiral phosphoric acid catalyst and substrates, which leads to the enantioselective C-C bond formation.

A fluoride activated methylene blue releasing platform for imaging and antimicrobial photodynamic therapy of human dental plaque

We report a F- activated methylene blue (MB) releasing platform for imaging and antimicrobial photodynamic therapy (aPDT). By utilizing this platform, one of the selected probes, FD-F3, displays a remarkable near-infrared fluorescence and absor

Carbonyl–Olefin Cross-Metathesis Through a Visible-Light-Induced 1,3-Diol Formation and Fragmentation Sequence

A visible-light-mediated approach to carbonyl–olefin cross-metathesis is described. Photoinduced hole catalysis was used to promote the formation of 1,3-diols from aldehydes and styrenes, which were then readily fragmented under acidic conditions to form the cross-metathesis products. The use of 1,3-diols as intermediates, rather than the energetically more demanding oxetanes, provides a new, orthogonal mechanistic strategy for carbonyl–olefin cross-metathesis. Furthermore, this approach does not require any metals, ligands, or additives, and provides the products with high levels of E selectivity. A mechanistic rationale is provided and supported by both theoretical calculations and experiments. Additionally, a practical synthesis of a new acridinium-based photocatalyst, including full characterization, is presented.

Synthesis method of isoliquiritigenin

The invention relates to the technical field of organic synthesis, and particularly discloses a synthesis method of isoliquiritigenin. According to the synthesis method of isoliquiritigenin, 2,4-hydroxyacetophenone and 4-hydroxybenzaldehyde are used as raw materials, and the product namely isoliquiritigenin can be obtained through hydroxyl protection, aldol condensation and hydroxyl deprotection reaction. The synthesis method of isoliquiritigenin, provided by the invention, is simple and easy to implement, mild in reaction conditions, safe, reliable, high in raw material availability, low in price and low in cost, adopts at least one of dimethyl tert-butyl chlorosilane and triisopropyl chlorosilane to protect 4-hydroxyl groups of 4-hydroxybenzaldehyde and 2,4-dihydroxyacetophenone, reducesthe risk of byproduct generation, improves the yield of isoliquiritigenin, and is suitable for industrial production.

Heterotelechelic Polymers by Ring-Opening Metathesis and Regioselective Chain Transfer

Heterotelechelic polymers were synthesized by a kinetic telechelic ring-opening metathesis polymerization method relying on the regioselective cross-metathesis of the propagating Grubbs’ first-generation catalyst with cinnamyl alcohol derivatives. This procedure allowed the synthesis of hetero-bis-end-functional polymers in a one-pot setup. The molecular weight of the polymers could be controlled by varying the ratio between cinnamyl alcohol derivatives and monomer. The end functional groups can be changed using different aromatically substituted cinnamyl alcohol derivatives. Different monomers were investigated and the presence of the functional groups was shown by NMR spectroscopy and MALDI-ToF mass spectrometry. Labeling experiments with dyes were conducted to demonstrate the orthogonal addressability of both chain ends of the heterotelechelic polymers obtained.

FLUORIDE FLUORESCENCE PROBE

Methylene blue (MB) derivatives selectively detect F? by desilylation reaction to act as a fluorescent probe.

A Modular Access to (±)-Tubocurine and (±)-Curine - Formal Total Synthesis of Tubocurarine

Two consecutive Cu-catalyzed Ullmann-type C-O couplings permitted the first successful entry toward the curare alkaloids (±)-tubocurine and (±)-curine. Starting from vanillin, the synthetic sequence comprises 15 linear steps and includes a total of 24 transformations. In addition, the total synthesis of tubocurine represents a formal total synthesis of the famous arrow poison alkaloid tubocurarine.

METABOLICALLY ROBUST ANALOGS OF CYP-EICOSANOIDS FOR THE TREATMENT OF CARDIAC DISEASE

The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs).The present invention further relates to composi