643090-88-4Relevant articles and documents
Total synthesis of cyclotheonamide C using a tandem backbone-extension- coupling methodology
Roche, Stephane P.,Faure, Sophie,Aitken, David J.
supporting information; experimental part, p. 6840 - 6842 (2009/04/06)
Mastering unusual amino acids: The first total synthesis of the potent protease inhibitor cyclotheonamide C (see structure representation) has been achieved. The key features of the synthesis are a three-component tandem procedure to create a masked α-keto-β-arginine within a peptide chain, and the control of the extended conjugation of a vinylogous α,β-dehydrotyrosine. (Chemical Equation Presented)
