211619-26-0

Basic information

• Product Name: (S)-2-Benzyl-4-oxo-azetidine-1-carboxylic acid methyl-(4-trifluoromethylsulfanyl-benzyl)-amide
• Synonyms: (S)-2-Benzyl-4-oxo-azetidine-1-carboxylic acid methyl-(4-trifluoromethylsulfanyl-benzyl)-amide
• CAS NO: 211619-26-0
• Molecular Weight: 408.444
• Mol File: 211619-26-0.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-Benzyl-4-oxo-azetidine-1-carboxylic acid methyl-(4-trifluoromethylsulfanyl-benzyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Benzyl-4-oxo-azetidine-1-carboxylic acid methyl-(4-trifluoromethylsulfanyl-benzyl)-amide(211619-26-0)
• EPA Substance Registry System: (S)-2-Benzyl-4-oxo-azetidine-1-carboxylic acid methyl-(4-trifluoromethylsulfanyl-benzyl)-amide(211619-26-0)

Safety Data

• Hazardous Substances Data: 211619-26-0(Hazardous Substances Data)

Upstream product

• 211618-75-6 3(S)-{{(benzyloxy)carbonyl}amino}-4-phenylbutyric acid benzyl ester 
• 1161-13-3 N-Cbz-L-Phe 
• 41518-17-6 Z-Phe-O-COO-isoBu 
• 15099-85-1 β-homo-(S)-phenylalanine 
• 15196-02-8 (S)-3-[(benzyloxycarbonyl)amino]-1-diazo-4-phenyl-2-butanone 

Relevant articles and documents

β-lactam derivatives as inhibitors of human cytomegalovirus protease

The development of novel monobactam inhibitors of HCMV protease incorporating a carbon side chain at C-4 and a urea function at N-1 is described. Substitution with small groups at the C-3 position of the β- lactam ring gave an increase in enzymatic activity and in stability; however, a lack of selectivity against other serine proteases was noted. The use of both triand tetrasubstituted urea functionalities gave effective inhibitors of HCMV protease. Benzyl substitution of the urea moiety was beneficial, especially when strong electron-withdrawing groups where attached at the para position. Modest antiviral activity was found in a plaque reduction assay.