211627-53-1Relevant articles and documents
Synthesis and in vitro and in vivo antifungal activity of the hydroxy metabolites of saperconazole
Meerpoel, Lieven,Heeres, Jan,Backx, Leo J. J.,Van Der Veken, Louis J. E.,Hendrickx, Rob,Corens, David,De Groot, Alex,Leurs, Stef,Van Der Eycken, Luc,Weerts, Johan,Luyts, Paul,Van Gerven, Frans,Woestenborghs, Filip A. A.,Van Breda, Andre,Oris, Michel,Van Dorsselaer, Pascal,Willemsens, Gustaaf H. M.,Bellens, Danny,Marichal, Patrick J. M. G.,Vanden Bossche, Hugo F.,Odds, Frank C.
experimental part, p. 757 - 769 (2011/02/23)
Herein we describe the scalable diastereoselective and enantio-selective syntheses of eight enantiomers of hydroxy metabolites of saperconazole. The in vitro antifungal activity of the eight stereoisomers (compounds 1-8) was compared against a broad panel
