211627-35-9

Upstream product

• 211627-53-1 2,4-dihydro-2-[(1S,2S)-2-hydroxy-1-methylpropyl]-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one 
• 64-19-7 acetic acid 
• 184177-81-9 phenyl N-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl)carbamate 
• 74853-08-0 1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine 

Downstream Products

• 211627-30-4 4-[4-[4-[4-[[(2S,4R)-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(1S,2S)-2-hydroxy-1-methylpropyl]-3H-1,2,4-triazol-3-one 
• 211627-46-2 4-[4-[4-[4-[[(2R,4S)-2-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-[(1S,2S)-2-hydroxy-1-methylpropyl]-3H-1,2,4-triazol-3-one 
• 148626-66-8 2S,4R,2'S,3'S hydroxy itraconazole 

Relevant academic research and scientific papers

Antifungal water-soluble compound as well as preparation method and application thereof (by machine translation)

The invention provides an antifungal water-soluble compound, a preparation method thereof and application, of the compound as I shown in formula. The compound has good antifungal effect and water solubility, can be used for treating and preventing,configuration optical isomers of the optical isomer SRSS obtained by chiral synthesis. (by machine translation)

Synthesis and in vitro and in vivo antifungal activity of the hydroxy metabolites of saperconazole

Herein we describe the scalable diastereoselective and enantio-selective syntheses of eight enantiomers of hydroxy metabolites of saperconazole. The in vitro antifungal activity of the eight stereoisomers (compounds 1-8) was compared against a broad panel