211676-86-7

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 211676-88-9 5'-O-(4,4'-dimethoxytrityl)-O²-methyluridine 
• 58-96-8 uridine 
• 53337-88-5 2-methoxy-1-β-D-ribofuranosyl-pyrimidine-4-one 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 53337-87-4 (3aR,4R,12R,12aR)-2,2,2-triphenyl-4,5,12,12a-tetrahydro-2H,3aH,8H-4,12-epoxy-2λ5-[1,3,2]dioxaphospholo[4,5-e]pyrimido[2,1-b][1,3]-oxazocin-8-one 

Relevant academic research and scientific papers

Incorporation of methylated pyrimidine analogues into RNA

Routes for the preparation of 2'-silyl protected phosphoramidites of the modified nucleosides O2-methyluridine and O4-methyluridine are described. Methodology for the site-specific incorporation of these phosphonamidetes into a 25 nucleotide long oligoribonucleotide sequence by solid-phase synthesis is reported.

Synthesis of Uridine Analogues to Probe the Functional Group Requirements of the Hairpin Ribozyme

O4-Methyluridine, O2-methyluridine and 4Huridine phosphoramidites were prepared with 2'-O-silyl protection.The methyl modified pyrimidines were synthesised from uridine via the triazolide (O4-methyl) or 2,5'-cyclo derivative (O2-methyl).An improved synthesis of protected 4-thiouridine was also performed.