53337-87-4Relevant articles and documents
Synthesis and Incorporation of k2U into RNA
Nainyte, Milda,Carell, Thomas
, (2020)
Lysidine (k2C) is one of the most modified pyrimidine RNA bases. It is a cytidine nucleoside, in which the 2-oxo functionality of the heterocycle is replaced by the ?-amino group of the amino acid lysine. As such, lysidine is an amino acid-cont
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
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Paragraph 0189-0190, (2019/07/14)
A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Synthesis of Uridine Analogues to Probe the Functional Group Requirements of the Hairpin Ribozyme
Vyle, Joseph S.,Young, Karen J.,Jones, Sarah,Grasby, Jane A.
, p. S280 - S282 (2007/10/03)
O4-Methyluridine, O2-methyluridine and 4Huridine phosphoramidites were prepared with 2'-O-silyl protection.The methyl modified pyrimidines were synthesised from uridine via the triazolide (O4-methyl) or 2,5'-cyclo derivative (O2-methyl).An improved synthesis of protected 4-thiouridine was also performed.