211746-19-9

Upstream product

• 54483-54-4 (+)-2β-hydroxyethyl-3-cyclopenten-1β-ol 
• 98-88-4 benzoyl chloride 
• 34638-25-0 (1R,5S)-2-oxabicyclo[3.3.0]oct-6-en-3-one 

Downstream Products

• 214471-26-8 (1R,2R)-2-(2-hydroxycyclopentyl)ethanol benzoyl ester 
• 214471-28-0 (1R,2S)-benzoic acid 2-[2-(6-chloro-9H-purin-9-yl)-2-cyclopentyl]ethyl ester 
• 214471-32-6 Benzoic acid 2-[(1R,2S)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentyl]-ethyl ester 

Relevant academic research and scientific papers

A Short and Stereoselective Synthesis of Carbocyclic alpha-L-Dideoxyhomonucleosides

A stereoselective five-step total synthesis of the hitherto unknown carbocyclic alpha-L-dideoxyhomonucleosides starting from readily available (1R,55)-2-oxabicyclo[3.3.0]oct-6-en-3-one is described.

Stereoselective synthesis of carbocyclic α-L-homonucleosides

The synthesis of several optically pure carbocyclic α-L-isomeric homonucleosides [3a-e, 6a,b, 7a,b, 10a-d] is reported. The (1R,5S)-2- oxabicyclo[3.3.0]oct-6-en-3-one 1 was used as a chiral starting material.

Synthesis of enantiomerically pure carbocyclic α-L-isomeric homonucleosides

Synthesis of hitherto unknown carbocyclic α-L-isomeric homonucleosides (8a-b, 9a-b) is described. The key intermediate 6 was synthesized from the known compound 1 as a chiral starting material. Construction of the heterocyclic moiety around the amino group of 6 afforded carbocyclic α-L- isomeric 2',3'-dideoxyhomonucleosides 8a-b and their 2',3'-didehydro-2',3'- dideoxy derivatives 9a-b.