211758-93-9Relevant academic research and scientific papers
Iridium-catalyzed triple C(sp3)-H borylations: Construction of triborylated sp3-carbon centers
Mita, Tsuyoshi,Ikeda, Yuto,Michigami, Kenichi,Sato, Yoshihiro
supporting information, p. 5601 - 5603 (2013/07/25)
An unprecedented catalytic C(sp3)-H triborylation at a single carbon was developed with the assistance of a nitrogen directing group.
Preparation of carbon-14 labeled N-(2-ethyl-3-chloro-4-pyridinyl)-4 -(4-chlorophenoxy)phenylacetamide
Pearson
, p. 151 - 157 (2007/10/03)
A 4-step modified route has been developed for the synthesis of N-(2-ethyl-3-chloro-4-pyridinyl-2-[14C])-4-(4-chloro- phenoxy)phenylacetamide ([14C]-1). The key transformation in the sequence is an amination/cyclization pair of reactions that furnished 2-[14C]-4-amino-2-ethylpyridine (4) from 5-[14C]-1-methoxyhept-1-en-3-yn-5-one (3) and ammonia. Amine 4 was then selectively chlorinated to provide 2-[14C]-4-amino-3-chloro-2-ethylpyridine (5) which was then coupled with 4-(4-chlorophenoxy)phenylacetic ethylformic anhydride (6) in a reaction mediated by trimethylaluminum to furnish the desired, radiolabeled phenylacetamide [14C]-1.
