211761-53-4

Upstream product

• 118684-32-5 [3-[N-(tert-butoxycarbonyl)amino]phenyl]methyl bromide 
• 145485-81-0 3-azido-7-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 1877-77-6 3-aminobenzenemethanol 
• 118684-31-4 tert-butyl N-[3-(hydroxymethyl)phenyl]carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 22245-89-2 7-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Downstream Products

• 213664-70-1 3-amino-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-7-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Relevant academic research and scientific papers

1,3-Disubstituted benzazepines as neuropeptide Y Y1 receptor antagonists

A novel class of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Through a blind screening we found the compound 1-N-(3-(N' -(tert-butoxycarbonyl)amino)benzyl)-7-methoxy-3-(3)-methylureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (9: IC50 =1.6 μM). Chemical modifications of 9 gave a potent NPY Y1 antagonist 3-(N-(4-hydroxyphenyl)-N0 -methylguanidino)-1-N-(3-(N'-(tert- butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (14c: IC50 =43 nM), which had no affnity for NPY Y2 and Y5 receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.