211801-61-5Relevant academic research and scientific papers
Total synthesis of 26-hydroxy-epothilone B and related analogs via a macrolactonization based strategy
Nicolaou,Finlay, M. Ray V.,Ninkovic, Sacha,Sarabia, Francisco
, p. 7127 - 7166 (2007/10/03)
The chemical synthesis of a series of 26-substituted epothilones B is described. Fully protected 26-hydroxydesoxy-epothilone B (7), prepared via the macrolactonization strategy, served as a common precursor to the designed epothilones described. The synthesized compounds were members of a large epothilone library whose biological screening led to the identification of a number of highly potent antitumor agents.
