211805-74-2

Basic information

• Product Name: 5-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-ol
• Synonyms: 5-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-ol
• CAS NO: 211805-74-2
• Molecular Weight: 254.329
• Mol File: 211805-74-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-ol(211805-74-2)
• EPA Substance Registry System: 5-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-ol(211805-74-2)

Safety Data

• Hazardous Substances Data: 211805-74-2(Hazardous Substances Data)

Upstream product

• 33892-75-0 5-Methoxy-1-tetralone 
• 100-44-7 benzyl chloride 
• 28315-93-7 5-Hydroxy-1-tetralone 
• 90401-60-8 5-benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-one 

Downstream Products

• 596845-77-1 1,5-bis(benzyloxy)-1,2,3,4-tetrahydronaphthalene 
• 314289-66-2 4-benzyloxy-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirane 
• 432036-79-8 5-benzyloxy-1,2,3,4-tetrahydro-2-oxonaphthalene 
• 432036-80-1 5-benzyloxy-1,23,4-tetrahydrospiro[naphthalene-2,2'-oxirane] 
• 314289-69-5 (5-benzyloxy-2-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)methanol 
• 432036-81-2 (-)-(1S,4R)-camphanic acid [(5-benzyloxy-2-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)methyl]ester 
• 432036-82-3 (-)-(1S,4R)-camphanic acid [((2R)-5-benzyloxy-2-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)methyl]ester 
• 432036-84-5 (-)-(1S,4R)-camphanic acid [((2S)-5-benzyloxy-2-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)methyl]ester 
• 432036-83-4 ((2R)-5-benzyloxy-2-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)methanol 
• 439142-73-1 ((2S)-5-benzyloxy-2-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)methanol 
• 432036-86-7 methanesulfonic acid [((2S)-5-benzyloxy-2-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)methyl]ester 
• 432036-85-6 C₁₉H₂₂O₅S 
• 314289-73-1 diphenylcarbamic acid [((2R)-5-benzyloxy-2-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)methyl]ester 
• 314289-74-2 diphenylcarbamic acid ((2R)-2,5-dihydroxy-1,2,3,4-tetrahydronaphth-2-yl)methyl ester 

Relevant articles and documents

The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase

Abstract: Monoamine oxidase (MAO) is of much clinical relevance, and inhibitors of this enzyme are used in the treatment for neuropsychiatric and neurodegenerative disorders such as depression and Parkinson’s disease. The present study synthesises and evaluates the MAO inhibition properties of a series of 33 1-tetralone and 4-chromanone derivatives in an attempt to discover high-potency compounds and to expand on the structure–activity relationships of MAO inhibition by these classes. Among these series, eight submicromolar MAO-A inhibitors and 28 submicromolar MAO-B inhibitors are reported, with all compounds acting as specific inhibitors of the MAO-B isoform. The most potent inhibitor was a 1-tetralone derivative (1h) with IC50 values of 0.036 and 0.0011?μM for MAO-A and MAO-B, respectively. Interestingly, with the reduction of 1-tetralones to the corresponding alcohols, a decrease in MAO inhibition potency is observed. Among these 1-tetralol derivatives, 1p (IC50 = 0.785?μM) and 1o (IC50 = 0.0075?μM) were identified as particularly potent inhibitors of MAO-A and MAO-B, respectively. Potent compounds such as those reported here may act as leads for the future development of MAO-B specific inhibitors. Graphic abstract: The present study describes the MAO inhibitory activities of a series of 1-tetralone and 4-chromanone derivatives. Numerous high-potency MAO-B specific inhibitors were identified.[Figure not available: see fulltext.].

A chemometric approach to map reaction media chemoselectivity: Example of selective debenzylation

A chemometric process consisting in measuring the reactivity of a set of substrates under standardized and complementary reaction conditions was run to evaluate the possibility of building a coherent database that would give a general overview of the sele