21197-34-2

Basic information

• Product Name: Cyclohexanepropanenitrile, 2-hydroxy-
• CAS NO: 21197-34-2
• Molecular Formula: C9H15NO
• Molecular Weight: 153.224
• Mol File: 21197-34-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexanepropanenitrile, 2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanepropanenitrile, 2-hydroxy-(21197-34-2)
• EPA Substance Registry System: Cyclohexanepropanenitrile, 2-hydroxy-(21197-34-2)

Safety Data

• Hazardous Substances Data: 21197-34-2(Hazardous Substances Data)

Upstream product

• 4594-78-9 cyclohexanone-2-propionitrile 
• 107-13-1 acrylonitrile 
• 110-83-8 cyclohexene 
• 108-94-1 cyclohexanone 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 

Downstream Products

• 4430-31-3 octahydrocoumarin 
• 29927-85-3 hexahydro-indan-1-one 
• 41010-09-7 3-cyclohexylpropionitrile 
• 88854-34-6 Imidazole-1-carbothioic acid O-[2-(2-cyano-ethyl)-cyclohexyl] ester 

Relevant articles and documents

Ytterbium-Catalyzed Intramolecular [3 + 2] Cycloaddition based on Furan Dearomatization to Construct Fused Triazoles

The 1,2,3-triazole-containing polycyclic architecture widely exists in a broad spectrum of synthetic bioactive molecules, and the development of expeditious methods to synthesize these skeletons remains a challenging task. In this work, the catalytic cyclization of biomass-derived 2-furylcarbinols with an azide to form fused triazoles is described. This approach takes advantage of a single catalyst Yb(OTf)3 and operates via a furfuryl-cation-induced intramolecular [3 + 2] cycloaddition/furan ring-opening cascade.

Enantioselective synthesis of cis-α-substituted cycloalkanols and trans-cycloalkyl amines thereof

The diastereo- and enantioselective syntheses of trans-cycloalkyl amines was accomplished through a three-step sequence consisting of: (1) asymmetric transfer hydrogenation through dynamic kinetic resolution of bicyclic and monocyclic α-substituted ketones using HCO2H/Et3N as the hydrogen source and TsDPEN-based Ru(II) catalysts, (2) nucleophilic hydroxyl to azide substitution of the resulting cis-cycloalkanols using diphenyl phosphoryl azide under modified Mitsunobu conditions, and (3) reduction of the trans-azide intermediates with LiAlH4 of PPh3/H2O to the desired targets.

PHASE TRANSFER CATALYSIS AND HOMOGENEOUS REACTIONS WITH β-OXYALKYL RADICALS FROM ORGANOMERCURIALS

β-Alkoxy- and β-hydroxyalkyl radicals generated by sodium borohydride reduction of oxymercurials react with electron deficient olefins to give addition compounds in a homogeneous process.Heterogeneous reactions are also successful in the presence of catalytic amounts of surfactants and provide a superior method for the "one pot" reductive alkylation of oxymercurials.