21202-42-6

Basic information

• Product Name: 4-(1H-IMIDAZOL-2-YL)-PYRIDINE
• Synonyms: 4-(1H-IMIDAZOL-2-YL)-PYRIDINE;4-(1H-2-IMIDAZOLYL)-PYRIDINE
• CAS NO: 21202-42-6
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.16128
• Mol File: 21202-42-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 210-211 °C(Solv: water (7732-18-5))
• Boiling Point: 395.1°C at 760mmHg
• Flash Point: 198.7°C
• Appearance: /
• Density: 1.214 g/cm³
• Vapor Pressure: 4.3E-06mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.50±0.10(Predicted)
• CAS DataBase Reference: 4-(1H-IMIDAZOL-2-YL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-IMIDAZOL-2-YL)-PYRIDINE(21202-42-6)
• EPA Substance Registry System: 4-(1H-IMIDAZOL-2-YL)-PYRIDINE(21202-42-6)

Safety Data

• Hazardous Substances Data: 21202-42-6(Hazardous Substances Data)

Usage

General Description

4-(1H-IMIDAZOL-2-YL)-PYRIDINE is a chemical compound with the molecular formula C9H7N3. It is a heterocyclic organic compound that consists of a pyridine ring fused to an imidazole ring. 4-(1H-IMIDAZOL-2-YL)-PYRIDINE is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and bioactive molecules. It exhibits potential pharmacological activities and has been studied for its potential use in the treatment of various diseases, including cancer, inflammation, and neurological disorders. Additionally, 4-(1H-IMIDAZOL-2-YL)-PYRIDINE is also used as a ligand in coordination chemistry and metal-organic frameworks due to its ability to form stable complexes with metal ions. Overall, 4-(1H-IMIDAZOL-2-YL)-PYRIDINE is an important and versatile compound with various potential applications in both pharmaceutical and chemical industries.

InChI:InChI=1/C8H7N3/c1-3-9-4-2-7(1)8-10-5-6-11-8/h1-6H,(H,10,11)

Upstream product

• 110-86-1 pyridine 
• 50846-98-5 2-Diazo-2H-imidazole 
• 100-48-1 pyridine-4-carbonitrile 
• 21381-61-3 4-(2-imidazolin-2-yl)pyridine 
• 872-85-5 pyridine-4-carbaldehyde 
• 131543-46-9 Glyoxal 
• 41365-75-7 aminopropane diethyl acetal 

Downstream Products

• 33468-83-6 4-(4-(trifluoromethyl)-1H-imidazol-2-yl)pyridine 

Relevant articles and documents

Ligand Induced Anionic Cuprous Cyanide Framework for Cupric Ion Turn on Luminescence Sensing and Photocatalytic Degradation of Organic Dyes

A new microporous luminescent coordination polymer [(CH3)2NH2]·[Cu2(CN)3] (1) with channels occupied by dimethylamine cations was synthesized due to the inducing effect of 2-(2′-pyridyl)imidazole. Complex 1 exhibits bright-green emission in the solid state, and its emission intensity would be significantly enhanced, especially by DMAc and cupric ion after immersing the as-synthesized crystals of 1 into common organic solvents or methanol solutions of various metal ions. In addition, 1 exhibits photocatalytic activity for the degradation of RhB and MB under natural light and is stable during the photocatalysis process. Thus, 1 can act as a multifunctional material for selectively sensing of Cu2+ and effectively photocatalytic degradation of dyes.

Silver(i) coordination chemistry: From 1-D chains to molecular rectangles

A series of silver(i) coordination compounds with the ligand 2-(4-pyridyl)imidazole 4-PyIm has been synthesized and crystallographically characterized in order to explore the role of counterions, solvents and ligand charge in the resulting supramolecular architectures. With perchlorate and hexafluorophosphate, two iso-structural 1-D coordination-polymers were obtained, but when changing the counterion to nitrate and using water as solvent, an unusual molecular rectangle composed of four ligands and four Ag(i) ions was obtained, and the assembly was controlled by hydrogen bonding via the anion and water molecules. Finally, when the ligand was deprotonated, the change in the number of binding sites (from two to three) was reflected in an increase in the coordination number for the silver ion.

Rapid and efficient biomimetic oxidation of 2-imidazolines to their corresponding imidazoles with NaIO4 catalyzed by Mn(salophen)Cl

Rapid and efficient oxidation of 2-substituted imidazolines with sodium periodate is reported. The Mn(III)-salophen/NaIO4 catalytic system efficiently converted 2-imidazolines to their corresponding imidazoles at room temperature in 2: 1, CH3CN/H2O mixture.