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41365-75-7

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41365-75-7 Usage

Chemical Properties

CLEAR COLOURLESS TO YELLOW LIQUID

Uses

1-Amino-3,3-diethoxypropane has been used:with alginate in the preparation of hydrogelin the generation of polyethylene glycol (PEG) polyethylenimine (PEI) polyplexes conjugate for transfection studies in hepatocellular carcinoma cell culturesas a component of pH-sensitive PEG derivative for lipopolyplexes formation

General Description

1-Amino-3,3-diethoxypropane is an effective modulator of alginate and chitosan based hydrogels and effectively used for the delivery of bone marrow stromal cells (BMSCs) for regeneration of cartilage.

Check Digit Verification of cas no

The CAS Registry Mumber 41365-75-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,3,6 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 41365-75:
(7*4)+(6*1)+(5*3)+(4*6)+(3*5)+(2*7)+(1*5)=107
107 % 10 = 7
So 41365-75-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H17NO2/c1-3-9-7(5-6-8)10-4-2/h7H,3-6,8H2,1-2H3/p+1

41365-75-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-AMINO-3,3-DIETHOXYPROPANE

1.2 Other means of identification

Product number -
Other names 1-Amino-3,3-diethoxypropane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:41365-75-7 SDS

41365-75-7Synthetic route

3-nitropropanal diethyl acetal
107833-73-8

3-nitropropanal diethyl acetal

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 7600.51 Torr; for 12h;98%
N-(3,3-diethoxypropyl)phthalimide
2453-90-9

N-(3,3-diethoxypropyl)phthalimide

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

Conditions
ConditionsYield
With hydrazine In methanol for 2h; Heating;87%
With hydrazine In methanol; dichloromethane70%
3,3-bis(ethyloxy)propanenitrile
2032-34-0

3,3-bis(ethyloxy)propanenitrile

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether for 16h; Ambient temperature;49%
With lithium aluminium tetrahydride
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

Conditions
ConditionsYield
With ethanol; ammonia
With sodium azide; hydrogen; palladium on activated charcoal 1.) DMF, 2.) C2H5OH, 4 d; Yield given. Multistep reaction;
Multi-step reaction with 2 steps
1: NaN3 / dimethylsulfoxide / 16 h / 50 °C
2: 8.2 g / H2 / 5 percent Pd/C / methanol / 2 h / 20 °C / 2585.74 Torr
View Scheme
Multi-step reaction with 2 steps
1: 83 percent / dimethylformamide / 5 h / 145 °C
2: 87 percent / hydrazine / methanol / 2 h / Heating
View Scheme
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

A

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

B

bis-(3,3-diethoxy-propyl)-amine
854253-50-2

bis-(3,3-diethoxy-propyl)-amine

Conditions
ConditionsYield
With ethanol; ammonia at 115 - 118℃;
3,3-diethoxypropionic amide
41365-74-6

3,3-diethoxypropionic amide

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether
3-chloro-propionaldehyde diethyl acetate

3-chloro-propionaldehyde diethyl acetate

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

Conditions
ConditionsYield
With ammonia at 80℃;
3-azidopropanal diethyl acetal
688317-69-3

3-azidopropanal diethyl acetal

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal; 5% Pd on active carbon In methanol at 20℃; under 2585.74 Torr; for 2h;8.2 g
ethyl 3,3-diethoxypropanoate
10601-80-6

ethyl 3,3-diethoxypropanoate

A

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

B

35 percent formaldehyde-solution

35 percent formaldehyde-solution

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NH3
2: LiAlH4 / diethyl ether
View Scheme
orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

SOCl2 (1 mol)

SOCl2 (1 mol)

A

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

B

35 percent formaldehyde-solution

35 percent formaldehyde-solution

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Zn / benzene
2: aq. NH3
3: LiAlH4 / diethyl ether
View Scheme
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1-(tert-butyloxycarbonylamino)-3,3-diethoxypropane
153815-24-8

1-(tert-butyloxycarbonylamino)-3,3-diethoxypropane

Conditions
ConditionsYield
In acetonitrile100%
In dichloromethane at 20℃; for 2h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 16.25h;94%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

2,2,2-Trichloroethyl chloroformate
17341-93-4

2,2,2-Trichloroethyl chloroformate

3-(2,2,2-trichloroethoxycarbonylamino)propionaldehyde diethyl acetal
380635-36-9

3-(2,2,2-trichloroethoxycarbonylamino)propionaldehyde diethyl acetal

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 2.16667h;100%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

methyl 4-aza-7,7-diethoxyhept-2-enoate

methyl 4-aza-7,7-diethoxyhept-2-enoate

Conditions
ConditionsYield
100%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

N-(3,3-diethoxypropyl)-4-methylbenzenesulfonamide
164532-58-5

N-(3,3-diethoxypropyl)-4-methylbenzenesulfonamide

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 10h;100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h;
With triethylamine In dichloromethane at 0 - 20℃;
With triethylamine In dichloromethane at 0℃; for 0.5h;
With triethylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid
956317-36-5

2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

N-(3,3-diethoxypropyl)-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide
1410040-78-6

N-(3,3-diethoxypropyl)-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Conditions
ConditionsYield
With N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 15h;100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;1.6 g
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

N-(4-chloro-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)-O,N-dimethylhydroxylamine
1610535-31-3

N-(4-chloro-6-prop-2-ynylamino-[1,3,5]triazin-2-yl)-O,N-dimethylhydroxylamine

N-[4-(3,3-diethoxypropylamino)-6-prop-2-ynylamino-[1,3,5]triazin-2-yl]-O,N-dimethylhydroxylamine
1610534-70-7

N-[4-(3,3-diethoxypropylamino)-6-prop-2-ynylamino-[1,3,5]triazin-2-yl]-O,N-dimethylhydroxylamine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 60℃; for 2h;100%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxylic acid
1268621-10-8

5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxylic acid

N-(3,3-diethoxypropyl)-5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

N-(3,3-diethoxypropyl)-5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Stage #1: 5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: aminopropane diethyl acetal In N,N-dimethyl-formamide at 20℃; for 0.166667h;
100%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

(S*)-3-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxylic acid

(S*)-3-methyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxylic acid

(S*)-N5-(3,3-diethoxypropyl)-N7,3-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide

(S*)-N5-(3,3-diethoxypropyl)-N7,3-dimethyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 1h;100%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

(S*)-3-ethyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxylic acid

(S*)-3-ethyl-7-(methylcarbamoyl)-3-phenyl-2,3-dihydrobenzofuran-5-carboxylic acid

(S*)-N5-(3,3-diethoxypropyl)-3-ethyl-N7-methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide

(S*)-N5-(3,3-diethoxypropyl)-3-ethyl-N7-methyl-3-phenyl-2,3-dihydrobenzofuran-5,7-dicarboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 1h;100%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

N-Fmoc-1-amino-3,3-diethoxypropane

N-Fmoc-1-amino-3,3-diethoxypropane

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;100%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

3-(3,4-dimethoxy-phenyl)-2-hydroxy-propionic acid methyl ester
54814-41-4, 54640-00-5, 54910-31-5

3-(3,4-dimethoxy-phenyl)-2-hydroxy-propionic acid methyl ester

(R)-(+)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide
170801-80-6

(R)-(+)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 140℃; for 2h;99%
pyrrol-2-yl trichloromethyl ketone
35302-72-8

pyrrol-2-yl trichloromethyl ketone

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

C12H20N2O3

C12H20N2O3

Conditions
ConditionsYield
In acetonitrile at 20℃; Inert atmosphere;99%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

methyl ethynyl ketone
1423-60-5

methyl ethynyl ketone

(3Z)-4-[(3,3-diethoxypropyl)amino]but-3-en-2-one

(3Z)-4-[(3,3-diethoxypropyl)amino]but-3-en-2-one

Conditions
ConditionsYield
In ethanol at 20℃; for 0.2h;99%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

p-(chloromethyl)benzoyl chloride
876-08-4

p-(chloromethyl)benzoyl chloride

4-(chloromethyl)-N-(3,3-diethoxypropyl)benzamide

4-(chloromethyl)-N-(3,3-diethoxypropyl)benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 3h;99%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

pentafluorobenzoylchloride
2251-50-5

pentafluorobenzoylchloride

2,3,4,5,6-pentafluoro-N-(3-oxopropyl)benzamide

2,3,4,5,6-pentafluoro-N-(3-oxopropyl)benzamide

Conditions
ConditionsYield
Stage #1: aminopropane diethyl acetal; pentafluorobenzoylchloride With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; Schlenk technique;
Stage #2: With hydrogenchloride; water In acetone for 1h; Inert atmosphere; Schlenk technique;
99%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid
1613414-00-8

4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid

(R)-quinuclidin-3-yl ((S)-(3-((4-((3,3-diethoxypropyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

(R)-quinuclidin-3-yl ((S)-(3-((4-((3,3-diethoxypropyl)carbamoyl)benzyl)oxy)phenyl)(phenyl)methyl)carbamate

Conditions
ConditionsYield
Stage #1: 4-((3-((S)-phenyl(((((R)-quinuclidin-3-yl)oxy)carbonyl)amino)methyl)phenoxy)methyl)benzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: aminopropane diethyl acetal at 20℃; for 18h;
99%
4‑chloro‑5‑bromo‑2‑(methylthio)pyrimidine
63810-78-6

4‑chloro‑5‑bromo‑2‑(methylthio)pyrimidine

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

5-bromo-N-(3,3-diethoxypropyl)-2-(methylsulfanyl)pyrimidin-4-amine

5-bromo-N-(3,3-diethoxypropyl)-2-(methylsulfanyl)pyrimidin-4-amine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 3h;98%
formaldehyd
50-00-0

formaldehyd

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

bis(4-methylphenyl)phosphinous acid
14655-66-4

bis(4-methylphenyl)phosphinous acid

(3,3-diethoxypropylaminomethyl)di-p-tolylphosphine oxide

(3,3-diethoxypropylaminomethyl)di-p-tolylphosphine oxide

Conditions
ConditionsYield
With toluene-4-sulfonic acid Kabachnik-Fields Reaction; Dean-Stark; Reflux;98%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

2,4-di-(β,β,β-trifluoroethoxy)-5-nitropyridine
79878-15-2

2,4-di-(β,β,β-trifluoroethoxy)-5-nitropyridine

4-(3',3'-diethoxypropylamino)-5-nitro-2-(β,β,β-trifluoroethoxy)-pyridine
79878-17-4

4-(3',3'-diethoxypropylamino)-5-nitro-2-(β,β,β-trifluoroethoxy)-pyridine

Conditions
ConditionsYield
In chloroform-d1 for 1h;97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

Methyl (S)-(+)-3-(3,4 dimethoxyphenyl)-2-hydroxypropionate
153381-08-9

Methyl (S)-(+)-3-(3,4 dimethoxyphenyl)-2-hydroxypropionate

(S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide
153309-68-3

(S)-(-)-N-(3,3-Diethoxypropyl)-3-(3,4-dimethoxyphenyl)-2-hydroxypropionamide

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 140℃; for 2h;97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

benzaldehyde
100-52-7

benzaldehyde

N-(3,3-diethoxypropyl)benzylamine hydrochloride
1099778-15-0

N-(3,3-diethoxypropyl)benzylamine hydrochloride

Conditions
ConditionsYield
With chloroform; 10% Pd/C; hydrogen In ethanol at 20℃; under 1551.49 Torr; for 10h; chemoselective reaction;97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

3-Fluorobenzaldehyde
456-48-4

3-Fluorobenzaldehyde

3-fluoro-N-(3,3-diethoxypropyl)benzylamine hydrochloride
1099778-13-8

3-fluoro-N-(3,3-diethoxypropyl)benzylamine hydrochloride

Conditions
ConditionsYield
With chloroform; 10% Pd/C; hydrogen In ethanol at 20℃; under 1551.49 Torr; for 10h; chemoselective reaction;97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

diethyl 2-(ethoxycarbonylmethylene)malonate
13049-86-0

diethyl 2-(ethoxycarbonylmethylene)malonate

C18H33NO8
1314160-55-8

C18H33NO8

Conditions
ConditionsYield
In dichloromethane at 20℃; for 18h;97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid
1268619-84-6

5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid

N-(3,3-diethoxypropyl)-5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxamide

N-(3,3-diethoxypropyl)-5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Stage #1: 5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: aminopropane diethyl acetal In N,N-dimethyl-formamide for 0.166667h;
97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

5-(4-{4-fluoro-3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxylic acid
1268619-99-3

5-(4-{4-fluoro-3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxylic acid

N-(3,3-diethoxypropyl)-5-(4-{4-fluoro-3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxamide

N-(3,3-diethoxypropyl)-5-(4-{4-fluoro-3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxamide

Conditions
ConditionsYield
Stage #1: 5-(4-{4-fluoro-3-[(3-methyl-2-furoyl)amino]phenoxy}pyridin-2-yl)-1H-pyrrole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: aminopropane diethyl acetal In N,N-dimethyl-formamide for 0.166667h;
97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-(3,3-diethoxypropyl)benzenesulfonamide

N-(3,3-diethoxypropyl)benzenesulfonamide

Conditions
ConditionsYield
With sodium carbonate In dichloromethane; water at 0℃; for 2h;97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

2-fluoro-5-chloronitrobenzene
345-18-6

2-fluoro-5-chloronitrobenzene

4-chloro-N-(3,3-diethoxypropyl)-2-nitroaniline

4-chloro-N-(3,3-diethoxypropyl)-2-nitroaniline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 4.5h;97%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 4.5h;97%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

4,7,10,13-tetraoxa-16-azaheneicosanoic acid 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-2,5-dioxo-1-pyrrolidinyl ester

4,7,10,13-tetraoxa-16-azaheneicosanoic acid 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-2,5-dioxo-1-pyrrolidinyl ester

C28H52N4O9S
1166397-67-6

C28H52N4O9S

Conditions
ConditionsYield
In dichloromethane at 20℃; for 3h;96%
aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

diphenylcarbamic chloride
83-01-2

diphenylcarbamic chloride

N'-(3,3-diethoxypropyl)-N,N-diphenylurea

N'-(3,3-diethoxypropyl)-N,N-diphenylurea

Conditions
ConditionsYield
With triethylamine In benzene96%

41365-75-7Relevant articles and documents

Synthetic studies on statins. Part 1: A short and cyanide-free synthesis of atorvastatin calcium via an enantioselective aldol strategy

Hu, Lemeng,Xiong, Fangjun,Chen, Xiaofei,Chen, Wenxue,He, Qiuqin,Chen, Fener

, p. 207 - 211 (2013/04/10)

A short and cyanide-free enantioselective synthesis of atorvastatin calcium has been achieved starting from a commercially available highly substituted 1,4-diketone in an overall yield of 40%. The key step in this approach is the asymmetric aldol reaction of an aldehyde with diketene in the presence of Ti(O-i-Pr)4-Schiff base complex to create the (5R)-stereochemistry of atorvastatin calcium.

Bifunctional polyethylene glycol derivatives

-

, (2008/06/13)

The present invention provides novel heterobifunctional and monobifunctional polyethylene glycol derivatives for the pegylation of therapeutically active proteins. The heterobifunctional PEGs which bear two different functional groups as well as the monobifunctional PEGs which contain two similar functional groups, may be used for cross-linking purposes. The cross-linking may be intramolecular between two areas within the same molecule or intermolecular between two separate molecules. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such bifunctional derivatives are described.

Tricyclic benzomorphan analogues by intramolecular Oxa-Pictet-Spengler reaction

Wunsch,Zott

, p. 2307 - 2310 (2007/10/02)

The key step in the regio- and stereoselective preparation of the benzomorphan analogues 9, 10a, 10b, 14 and 15 is an intramolecular Oxa-Pictet-Spengler reaction. Masked as an acetal the carbonyl component is connected via an amide to the 2-phenylethanol component (7, 12).

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