212119-80-7Relevant academic research and scientific papers
A new silyl linker for reverse-direction solid-phase peptide synthesis
Lipshutz, Bruce H.,Shin, Young-Jun
, p. 5629 - 5633 (2001)
Treatment of a free amino acid ester with CO2 followed by exposure to a chlorosilane-containing polystyrene results in its attachment to the solid support. The newly formed silyl carbamate can be employed to build polypeptides at the carboxyl terminus. Cleavage of the (poly)peptide using aqueous HF in CH3CN leads to its free amine form which is isolated as a Boc derivative. The polymer support can be easily recycled.
The (2-phenyl-2-trimethylsilyl)ethoxycarbonyl (Psoc) group - A novel amino protecting group
Wagner,Heiner,Kunz
, p. 1753 - 1756 (2007/10/03)
A novel silicon containing protecting group has been developed based on the known 2-(trimethylsilyl)ethyl system. The new protecting group is cleaved under very mild conditions by treatment with tetra-n-butylammonium fluoride in CH2Cl2 much more rapidly than the 2-(trimethylsilyl)ethoxycarbonyl group, leading to less side reactions.
New phenylfluorenyl based linkers for solid phase synthesis
Bleicher,Lutz,Wuthrich
, p. 9037 - 9042 (2007/10/03)
The synthesis of 9-(4-hydroxyphenyl)-9-H-fluoren-9-ol and 5-(4-(9-hydroxy-9H-fluoren-9-yl)-phenoxy)-pentanoic acid and their applications as new linkers for solid phase synthesis is reported. These supports show higher acid stability compared to standard trityl resins. Carboxylic acids and amines are immobilized and cleaved off after further modifications. TFA treatment releases the products in high yield and excellent purity. (C) 2000 Elsevier Science Ltd.
Chemoenzymatic synthesis of N-Ras lipopeptides
N?gele, Edgar,Schelhaas, Michael,Kuder, Norman,Waldmann, Herbert
, p. 6889 - 6902 (2007/10/03)
For the study of biological phenomena influenced by the plasma-membrane- bound Ras proteins and other lipidated proteins, characteristic peptides which embody the correct lipid modifications of their parent proteins (palmitoyl thioesters and farnesyl thio
Synthese des palmitoylierten und farnesylierten C-terminalen Lipohexapeptids des menschlichen N-Ras-Proteins mit Hilfe einer enzymatisch abspaltbaren Urethanschutzgruppe
Waldmann, Herbert,Naegele, Edgar
, p. 2425 - 2428 (2007/10/03)
Keywords: Bioorganische Chemie, Enzyme, Ras-Proteine, Schutzgruppen
