212127-80-5 Usage
Description
2-(2,5-Dihydrofuran-3-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane is a chemical compound derived from 3-Oxotetrahydrofuran (O870480), which is utilized as a reagent in the synthesis of dihydropteridinone. 2-(2,5-Dihydrofuran-3-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane plays a significant role in the preparation of orally active Polo-like kinase-2 (Plk-2) inhibitors, which are essential in various pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
2-(2,5-Dihydrofuran-3-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane is used as a key intermediate compound for the development of orally active Polo-like kinase-2 (Plk-2) inhibitors. These inhibitors are crucial in the treatment of various diseases, including cancer, due to their ability to target and inhibit the activity of Plk-2, a protein involved in cell division and regulation.
The compound is particularly valuable in the pharmaceutical industry because it serves as a building block for the synthesis of Plk-2 inhibitors, which have demonstrated potential in treating a range of diseases. By targeting Plk-2, these inhibitors can help regulate cell division and prevent the uncontrolled growth of cells, which is a hallmark of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 212127-80-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,2,1,2 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 212127-80:
(8*2)+(7*1)+(6*2)+(5*1)+(4*2)+(3*7)+(2*8)+(1*0)=85
85 % 10 = 5
So 212127-80-5 is a valid CAS Registry Number.
212127-80-5Relevant articles and documents
Multigram Synthesis of Heterabicyclo[n.1.0]alkan-1-yl Trifluoroborates
Kleban, Ihor,Krokhmaliuk, Yevhen,Reut, Sofiia,Shuvakin, Serhii,Pendyukh, Vyacheslav V.,Khyzhan, Oleksandr I.,Yarmoliuk, Dmytro S.,Tymtsunik, Andriy V.,Rassukana, Yuliya V.,Grygorenko, Oleksandr O.
, p. 6551 - 6560 (2020/09/17)
An approach to the synthesis of oxa- and azabicyclo[n.1.0]alkan-1-yl trifluoroborates on a multigram scale was developed. Two synthetic strategies were evaluated: the first based on the lithiation–borylation of the corresponding 2-bromoallyl derivatives, and the other relying on regioselective hydroboration of the appropriate hetera-substituted enynes. The second method appeared to be more efficient in terms of scalability and substrate scope. Further steps included ring closing-metathesis, mild palladium-catalyzed cyclopropanation with diazomethane, and reaction with KHF2 and furnished the title compounds in up to 50 g scale in a single run (10–41 % overall yield, 4–5 steps).
Novel synthesis of cyclic alkenylboronates via ring-closing metathesis [12]
Renaud,Ouellet
, p. 7995 - 7996 (2008/10/08)
-
