212136-31-7

Basic information

• Product Name: ethyl (2S,3R)-3-hydroxy-2-methyl-2-(methylthio)-3-phenylpropanoate
• Synonyms: ethyl (2S,3R)-3-hydroxy-2-methyl-2-(methylthio)-3-phenylpropanoate
• CAS NO: 212136-31-7
• Molecular Weight: 254.35
• Mol File: 212136-31-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl (2S,3R)-3-hydroxy-2-methyl-2-(methylthio)-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2S,3R)-3-hydroxy-2-methyl-2-(methylthio)-3-phenylpropanoate(212136-31-7)
• EPA Substance Registry System: ethyl (2S,3R)-3-hydroxy-2-methyl-2-(methylthio)-3-phenylpropanoate(212136-31-7)

Safety Data

• Hazardous Substances Data: 212136-31-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1051925-20-2 (E/Z)-1-ethoxy-1-(trimethylsiloxy)-2-methylthiopropene 
• 40800-76-8 2-methylsulfanyl-propionic acid ethyl ester 

Downstream Products

• 155320-73-3 Ethyl (2S,3S)-3-hydroxy-2-methyl-3-phenylpropionic acid 
• 192135-52-7 (2R,3S)-3-hydroxy-2-methyl-3-phenyl-propionic acid ethyl ester 

Relevant articles and documents

Enantioselective synthesis of β-hydroxy-α-methyl-α-methylthio esters as precursors of anti-vic-hydroxymethyl units

A new method for the synthesis of optically active anti-vic-hydroxymethyl units that correspond to anti-aldol derivatives is developed by way of successive enantioselective aldol and diastereoselective desulfurization reactions.

Highly enantioselective synthesis of syn- and anti-propionate aldols without diastereoselection in the chiral oxazaborolidinone-promoted aldol reaction with a silyl ketene acetal derived from ethyl 2- (methylthio)propionate

A mixture of syn- and anti-aldol products containing an α-methylthio group were obtained in good yields with high enantioselectivities in the chiral oxazaborolidinone-promoted aldol reactions of a novel silyl ketene acetal, derived from ethyl 2-(methylthio)propionate, with aldehydes. Subsequent desulfurization resulted in an effective preparation of essentially enantiopure syn- and anti-propionate aldols which were separable.