21218-55-3

Basic information

• Product Name: 2-(4-benzylpiperazin-1-yl)-4,6-dimorpholino-1,3,5-triazine
• Synonyms: 2-(4-benzylpiperazin-1-yl)-4,6-dimorpholino-1,3,5-triazine
• CAS NO: 21218-55-3
• Molecular Weight: 425.534
• Mol File: 21218-55-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-benzylpiperazin-1-yl)-4,6-dimorpholino-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-benzylpiperazin-1-yl)-4,6-dimorpholino-1,3,5-triazine(21218-55-3)
• EPA Substance Registry System: 2-(4-benzylpiperazin-1-yl)-4,6-dimorpholino-1,3,5-triazine(21218-55-3)

Safety Data

• Hazardous Substances Data: 21218-55-3(Hazardous Substances Data)

Upstream product

• 6601-22-5 2,6-Dichloro-4-morpholino-1,3,5-triazine 
• 2759-28-6 1-phenylmethylpiperazine 
• 7597-22-0 2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine 

Relevant articles and documents

Synthesis and antibacterial activity of some novel 4-benzyl-piperazinyl-s- triazine derivatives

Considerable interest has been attracted in s-triazine scaffold and its derivatives because of their large variety of pharmacological activities. In this project, a series of 4-benzyl-piperazinyl-s-triazine derivatives 5a to 5j were synthesized by three steps substitution reaction of cyanuric chloride with various nucleophilic compounds in presence of a base. Molecular structures of the synthesized compounds were elucidated by FTIR, 1H NMR, 13C NMR, MS spectral data and elemental analyses. The in vivo antibacterial activity was evaluated by broth dilution method against representative four Gram-positive and four Gram-negative bacterial strains. Many compounds have displayed comparable better antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermis and Pseudomonas aeruginosa with reference to streptomycin.