212311-55-2Relevant academic research and scientific papers
Syntheses of 2-(bromodifluoromethyl)benzoxazole and 5-(bromodifluoromethyl)-1,2,4-oxadiazoles
Dolbier Jr., William R.,Burkholder, Conrad R.,Medebielle, Maurice
, p. 127 - 130 (2007/10/03)
Facile syntheses of CF2Br-substituted heterocycles are reported. Preparation of 2-(bromodifluoromethyl)benzoxazole (2) was achieved in two steps by reaction of 2-aminophenol (3) with CF2BrCO2Et to give amide (4), followed by cyclization of 4 with PPA to give 2. The 5-(bromodifluoromethyl)-1,2,4-oxadiazoles (6a-c) were prepared by one step reaction of amidoximes (5a-c) with CF2BrCO2Et. These CF2Br-substituted heterocycles are intermediates in an ongoing investigation of the synthesis of inhibitors of HIV reverse transcriptase having a CF2 substitution.
