21232-80-4Relevant academic research and scientific papers
Understanding the p-toluenesulfonamide/triphenylphosphine oxide crystal chemistry: A new 1:1 cocrystal and ternary phase diagram
Croker, Denise M.,Foreman, Michael E.,Hogan, Bridget N.,Maguire, Nuala M.,Elcoate, Curtis J.,Hodnett, Benjamin K.,Maguire, Anita R.,Rasmuson, Ake C.,Lawrence, Simon E.
, p. 869 - 875 (2012)
A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state. The ternary phase diagram for the two coformers was constructed in two different solvents: Acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system.
Solution mediated phase transformations between co-crystals
Croker, Denise M.,Davey, Roger J.,Rasmuson, Ake C.,Seaton, Colin C.
, p. 2044 - 2047 (2013/04/10)
A solution mediated transformation between two co-crystal phases has been observed for the p-toluensulfonamide-triphenylphosphine oxide co-crystal system. This system has two known co-crystals with 1 : 1 and 3 : 2 stoichiometry respectively, and the ternary phase diagram (TPD) for the system has been determined in acetonitrile previously. By manipulating the solution composition in this solvent to a region of the TPD where the 1 : 1 co-crystal is stable, the 3 : 2 co-crystal could be observed to convert to the 1 : 1 co-crystal. The corresponding transformation was true for the 1 : 1 co-crystal in a region of the TPD where the 3 : 2 co-crystal is stable; the 1 : 1 co-crystal converted to the 3 : 2 co-crystal.
