212329-32-3

Upstream product

• 3359-24-8 2-(2-phenyl-2H-1,2,3-triazole-4-yl)methanol 
• 77-78-1 dimethyl sulfate 
• 124-41-4 sodium methylate 

Relevant academic research and scientific papers

Nitration of 4-Substituted 2-Phenyl-1,2,3-triazoles

Substituent in position 4 of the heteroring influences the nitration of 2-phenyl-1,2,3-triazoles. Electron-donor substituents favor nitration at the heteroring.

1,2,3-Triazoles produced from 5-Substituted N-Methoxytriazolium Salts

Five reactions, two of which are new, have been observed when 5-substituted 1-methoxy-2-phenyltriazolium salts react with nucleophiles: (i) addition to C-4 with elimination of methanol to give unsymmetrically 4,5-disubstituted triazoles; (ii) displacement of the 5-substituent followed by secondary reactions to give a symmetrically 4,5-disubstituted triazole, a 5-substituted triazole N-oxide, a 4-substituted triazole, or a disubstituted benzeneazoacetonitrile; (iii) deprotonation of the N-methoxy-group with elimination of formaldehyde; (iv) demethylation; (v) abstraction of an α-proton from a 5-alkyl group followed by nucleophilic addition and elimination of methanol to give an α-substituted 5-alkyltriazole.The reactions are of synthetic potential as a means of introducing one or two substituents in the 1,2,3-triazole system.