21237-55-8Relevant academic research and scientific papers
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators
Piemontese, Luca,Laghezza, Antonio,Fracchiolla, Giuseppe,Carbonara, Giuseppe,Tortorella, Paolo,Loiodice, Fulvio
, p. 791 - 795 (2013/08/23)
2H-1,4-Benzoxazine amidine derivatives are drugs acting as modulators of the skeletal muscle and pancreatic beta cell ATP-sensitive-K+ (KATP) channels. With the aim of evaluating the influence of absolute configuration on the biological activity of these drugs, we herein report the optimization of a synthetic route to obtain both enantiomers of some of these compounds with improved chemical yield and high enantiomeric excess.
