212384-28-6Relevant articles and documents
Preparation method of carbendazim
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Paragraph 0015, (2021/08/25)
The invention discloses a preparation method of carbendazim. According to the method, carbendazim is prepared through acylation reaction which is mild in reaction condition and extremely high in reaction efficiency. The optimal preparation method of carbendazim is screened through a large number of experiments, the whole process is reasonable in design, and the process is easy to operate and efficient. Meanwhile, the reaction yield can be greatly increased (up to 92% or above), side reactions can be reduced, the reaction efficiency can be improved, the energy consumption required by the reaction can be reduced, the production cost can be greatly reduced, and the method has a very good application prospect.
Carbendazim preparation technology
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Paragraph 0007; 0015, (2017/01/17)
The invention discloses a carbendazim preparation method. Being improved based on a traditional synthesis technology, the carbendazim preparation method is characterized in that firstly, a methylbenzene and water biphasic solvent reaction system is adopted, so that carbendazim appearance is improved, carbendazim is bright white, purity can be above 99.8% and carbendazim grade is increased; secondly, a method that concentrated hydrochloric acid and a methyl cyanocarbamate cyclizing agent are added dropwise simultaneously is adopted, and carbendazim yield can be above 97.5%. Compared with an existing traditional synthesis technology, the carbendazim preparation method has the greatest advantages that carbendazim yield is high, and the carbendazim is excellent in color and luster and high in purity, thereby being a method capable of preparing the high-quality carbendazim.
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H- benzo[d]imidazol-2-yl carbamate derivatives
Liu, Xuefei,Chen, Qianqian,Zhu, Ju,Fan, Yongzheng,Ding, Lili,Zhao, Juntao,Han, Guangqian,Tian, Wei,Qi, Jingjing,Zhou, Youjun,Lv, Jiaguo
scheme or table, p. 3554 - 3559 (2012/06/18)
A series of novel methyl 5-substituted 1H-benzo[d]imidazol-2-ylcarbamates were designed, synthesized, and their acrosin inhibitory activities evaluated in vitro. The results of acrosin inhibitory activity showed that all title compounds were more potent than the control TLCK. Compound 4w displayed the most potent acrosin inhibitory activity among all the compounds, with an IC 50 of 6.3 × 10-5 M. The studies provide a new structural class for the development of novel acrosin inhibitory agents.