21239-87-2 Usage
Explanation
Different sources of media describe the Explanation of 21239-87-2 differently. You can refer to the following data:
1. The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 9 carbon atoms, 8 hydrogen atoms, 4 nitrogen atoms, and 1 sulfur atom.
2. This structure indicates that the compound is a triazole derivative with a phenylmethylthio group attached to the third carbon of the triazole ring.
3. The compound is derived from the triazole ring, which is a five-membered ring containing three nitrogen atoms and two carbon atoms.
4. The phenylmethylthio group is a functional group consisting of a phenyl ring attached to a methyl group, which is further connected to a sulfur atom.
5. The compound is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It also exhibits biological activity and has been studied for its potential as an anti-cancer and anti-inflammatory agent. Additionally, it has shown potential as a corrosion inhibitor and as a ligand in coordination chemistry.
6. The compound has been found to have biological activity, which means it can interact with living organisms and potentially produce an effect or response.
7. Research has been conducted to explore the compound's potential as an anti-cancer agent, which could lead to the development of new cancer treatments.
8. The compound has also been studied for its potential as an anti-inflammatory agent, which could be useful in the development of new treatments for inflammatory conditions.
9. The compound has demonstrated potential as a corrosion inhibitor, which could be applied in various industries to protect materials from corrosion.
10. The compound has shown potential as a ligand in coordination chemistry, which could be used to form complexes with metal ions and study their properties and applications.
Chemical Structure
1H-1,2,4-Triazole, 3-[(phenylmethyl)thio]-
Triazole Derivative
Yes
Phenylmethylthio Group
Attached to the third carbon of the triazole ring
Applications
Pharmaceutical and agrochemical synthesis, anti-cancer and anti-inflammatory agent, corrosion inhibitor, and coordination chemistry ligand
Biological Activity
Exhibited
Potential as an Anti-cancer Agent
Studied
Potential as an Anti-inflammatory Agent
Studied
Corrosion Inhibition
Shown potential
Coordination Chemistry Ligand
Shown potential
Check Digit Verification of cas no
The CAS Registry Mumber 21239-87-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,3 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 21239-87:
(7*2)+(6*1)+(5*2)+(4*3)+(3*9)+(2*8)+(1*7)=92
92 % 10 = 2
So 21239-87-2 is a valid CAS Registry Number.
21239-87-2Relevant articles and documents
Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials
McConville, Matthew,Fernández, Jorge,Angulo-Barturen, í?igo,Bahamontes-Rosa, Noemi,Ballell-Pages, Lluis,Casta?eda, Pablo,De Cózar, Cristina,Crespo, Benigno,Guijarro, Laura,Jiménez-Díaz, María Belén,Martínez-Martínez, Maria S.,De Mercado, Jaime,Santos-Villarejo, ángel,Sanz, Laura M.,Frigerio, Micol,Washbourn, Gina,Ward, Stephen A.,Nixon, Gemma L.,Biagini, Giancarlo A.,Berry, Neil G.,Blackman, Michael J.,Calderón, Félix,O'Neill, Paul M.
supporting information, p. 6448 - 6455 (2015/09/08)
(Graph Presented) Screening of the GSK corporate collection, some 1.9 million compounds, against Plasmodium falciparum (Pf), revealed almost 14000 active hits that are now known as the Tres Cantos Antimalarial Set (TCAMS). Followup work by Calderon et al.
Synthesis and antimycobacterial activity of 1,2,4-triazole 3-benzylsulfanyl derivatives
Klimesova, Vera,Zahajska, Lenka,Waisser, Karel,Kaustova, Jarmila,Moellmann, Ute
, p. 279 - 288 (2007/10/03)
Series of 3-benzylsulfanyl derivatives of 1,2,4-triazole and 4-methyl-1,2,4-triazole were synthesized by alkylation of starting triazole-3-thiol with appropriately substituted benzyl halide. All members of the set were evaluated for in vitro antimycobacte
A Unified Approach to Systematic Isoesteric Substitution for Acidic Groups and Application to NMDA Antagonists Related to 2-Amino-7-phosphonoheptanoate
Chenard, B. L.,Lipinski, C. A.,Dominy, B. W.,Mena, E. E.,Ronau, R. T.,et al.
, p. 1077 - 1083 (2007/10/02)
A systematic approach to the replacement of acidic groups with potential bioisoesteres is described.The strategy involves simple nucleophilic displacement of a common alkyl halide precursor with a variety of mercaptoazoles and related molecules.The mercaptoazoles and their oxidized derivatives (sulfinyl- and sulfonylazoles) represent a series of possible surrogates for acidic groups which span a pKa range from about 4.5-11.5.This simple strategy was extended to include 2-hydroxy- or 2-aminothiophenyl groups which function as relatively nonacidic isoesteres for a phosphonic acid.By replacing the phosphonic acid of 2-amino-7-phosphonoheptanoate (AP-7) with these groups, we have synthesized novel N-methyl-d-aspartate (NMDA) antagonists.
