21244-35-9

Upstream product

• 40141-13-7 1-butoxy-4-(chloromethyl)benzene 
• 5736-88-9 p-butoxybenzaldehyde 
• 5203-14-5 4-butoxybenzonitrile 
• 767-00-0 4-cyanophenol 

Downstream Products

• 55383-80-7 N-(4-butoxy-benzyl)-β-alanine nitrile 
• 100861-97-0 N-(4-butoxy-benzyl)-β-alanine amide 
• 87578-63-0 N-(p-butoxybenzyl)formamide 
• 85501-76-4 N-[4-(4-Butoxy-benzylamino)-6-chloro-2-methyl-pyrimidin-5-yl]-acetamide 
• 1262323-55-6 C₄₄H₅₁N₅O₅ 
• 1262323-43-2 C₃₆H₃₈N₄O₂ 
• 102320-98-9 (4-butoxy-benzyl)-(2-phenoxy-ethyl)-amine 
• 18743-48-1 4-butoxy-benzyl isothiocyanate 

Relevant academic research and scientific papers

N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: Analysis of structure-activity relationships for the 'C-Region'

We recently reported that N-(4-t-butylbenzyl)-N′-[4- (methylsulfonylamino)benzyl] thiourea (2) was a high affinity antagonist of the vanilloid receptor with a binding affinity of Ki=63 nM and an antagonism of Ki=53.9 nM in rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells (Mol. Pharmacol. 2002, 62, 947-956). In an effort to further improve binding affinity and antagonistic potency, we have modified the C-region of the lead 4-t-butylbenzyl group with diverse surrogates, such as araalkyl, alkyl, 4-alkynylbenzyl, indanyl, 3,3-diarylpropyl, 4-alkoxybenzyl, 4-substituted piperazine and piperidine. The lipophilic surrogates, arylalkyl and alkyl, conferred modest decreases in binding affinities and antagonistic potencies; the groups having heteroatoms resulted in dramatic decreases. Our findings indicate that 4-t-butylbenzyl is one of the most favorable groups for high receptor binding and potent antagonism to VR1 in this structural series.

Method for treating glaucoma

Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.

Prevention of loss and restoration of bone mass by certain prostaglandin agonists

Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis. STR1

Design of Inhibitors from the Three-Dimensional Structure of Alcohol Dehydrogenase. Chemical Synthesis and Enzymatic Properties

Inhibitors of liver alcohol dehydrogenase were designed from the three-dimensional structure of the enzyme.The ligand to the catalytic zinc ion is an amide group or, better, a formamide group.With the latter function, a hydrogen bond between the NH group and the hydroxyl group of Ser-48 may be formed.The hydrophobic substrate binding site brings structural restraints. α-ω bifunctional molecules show good inhibitory properties possibly due to the interactions with polar residues at the entrance of the substrate binding site.