21244-35-9

Basic information

• Product Name: 4-BUTOXYBENZYLAMINE
• Synonyms: RARECHEM AL BW 0508;4-BUTOXYBENZYLAMINE;4-BUTYLOXYBENZYLAMINE
• CAS NO: 21244-35-9
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.26
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 21244-35-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-BUTOXYBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BUTOXYBENZYLAMINE(21244-35-9)
• EPA Substance Registry System: 4-BUTOXYBENZYLAMINE(21244-35-9)

Safety Data

• Hazardous Substances Data: 21244-35-9(Hazardous Substances Data)

Upstream product

• 5736-88-9 p-butoxybenzaldehyde 
• 767-00-0 4-cyanophenol 
• 5203-14-5 4-butoxybenzonitrile 
• 40141-13-7 1-butoxy-4-(chloromethyl)benzene 

Downstream Products

• 1262323-55-6 C₄₄H₅₁N₅O₅ 
• 1262323-43-2 C₃₆H₃₈N₄O₂ 
• 85501-76-4 N-[4-(4-Butoxy-benzylamino)-6-chloro-2-methyl-pyrimidin-5-yl]-acetamide 
• 87578-63-0 N-(p-butoxybenzyl)formamide 
• 102320-98-9 (4-butoxy-benzyl)-(2-phenoxy-ethyl)-amine 
• 100861-97-0 N-(4-butoxy-benzyl)-β-alanine amide 
• 55383-80-7 N-(4-butoxy-benzyl)-β-alanine nitrile 
• 18743-48-1 4-butoxy-benzyl isothiocyanate 

Relevant articles and documents

N-[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: Analysis of structure-activity relationships for the 'C-Region'

We recently reported that N-(4-t-butylbenzyl)-N′-[4- (methylsulfonylamino)benzyl] thiourea (2) was a high affinity antagonist of the vanilloid receptor with a binding affinity of Ki=63 nM and an antagonism of Ki=53.9 nM in rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells (Mol. Pharmacol. 2002, 62, 947-956). In an effort to further improve binding affinity and antagonistic potency, we have modified the C-region of the lead 4-t-butylbenzyl group with diverse surrogates, such as araalkyl, alkyl, 4-alkynylbenzyl, indanyl, 3,3-diarylpropyl, 4-alkoxybenzyl, 4-substituted piperazine and piperidine. The lipophilic surrogates, arylalkyl and alkyl, conferred modest decreases in binding affinities and antagonistic potencies; the groups having heteroatoms resulted in dramatic decreases. Our findings indicate that 4-t-butylbenzyl is one of the most favorable groups for high receptor binding and potent antagonism to VR1 in this structural series.

Prevention of loss and restoration of bone mass by certain prostaglandin agonists

Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis. STR1