21254-74-0

Usage

Uses

Used in Polymer and Resin Synthesis:
2,4,6-tris(piperidin-1-yl)-1,3,5-triazine is used as a crosslinking agent for enhancing the adhesion and cohesion of various materials. Its presence in the synthesis process improves the overall performance and durability of polymers and resins.
Used in Manufacturing of Adhesives, Coatings, and Plastics:
2,4,6-tris(piperidin-1-yl)-1,3,5-triazine is utilized in the production of adhesives, coatings, and plastics due to its ability to strengthen the bonding and cohesive properties of these materials, resulting in higher quality and more reliable end products.
Used in Drug Delivery Systems:
2,4,6-tris(piperidin-1-yl)-1,3,5-triazine has been studied for its potential use in drug delivery systems, where it could contribute to the controlled release of pharmaceutical agents and improve the overall effectiveness of drug administration.
Used as a Catalyst in Organic Synthesis:
2,4,6-tris(piperidin-1-yl)-1,3,5-triazine has also been explored for its potential as a catalyst in organic synthesis, where it could facilitate various chemical reactions and improve the efficiency of the synthesis process.
It is important to handle 2,4,6-tris(piperidin-1-yl)-1,3,5-triazine with care, as it may pose health and environmental hazards if not used properly.

Upstream product

• 110-89-4 piperidine 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 5759-58-0 2,4,6-tris(methylthio)-1,3,5-triazine 
• 1530-87-6 1-piperidinylcarbonnitrile 
• 103-70-8 Formanilid 
• 626-67-5 N-methylcyclohexylamine 

Downstream Products

• 110-89-4 piperidine 
• 108-80-5 isocyanuric acid 

Relevant academic research and scientific papers

Reactions of bis(silyl-substituted) methyllithium with α-hydrogen- free nitriles into 1,3,5-triazines

Bis(silyl-substituted) methyllithium has been found to catalyze a conversion of α-hydrogen-free nitriles directly to yield 2,4,6-trisubsituted s-triazines. The generally high yields and relatively mild reaction conditions of this procedure suggest an alternative to other aromatic nitrile cyclotrimerization reactions. Silicotropic rearrangements from C to N or N to N and an unusual elimination of LiCR2R (R=SiMe3, R=SiMe2NMe2) were observed.

Addition reactions of bis(trimethylsilyl)methyl- and 1-azzallyl-lithium with cyanoamines into triazines or β-diketiminatolithium compounds

Reactions of bis(trimethylsily)methyl lithium reagent Li[CHR2] (R = SiMe3) and 1-azaallyllithium, [LiN(R)C(But) CHR]2 with cyanoamines R′CN (R' = Me2N, 1-piperidyl or o, p-pyridyl) yielded β-diketiminatolithiums (1, 2, 5, 7, 8) or symmetrically and mixed substituted triazines (3, 4, 6, 9, 10), respectively. The mechanistic pathways involve silicotropic rearrangements from C to N or N to N and an unusual elimination of Li[CHR2]. The complexes 1, 6, 7, and 10 had been characterized by X-Ray diffraction.

Synthesis, Spectra, and Theoretical Investigations of 1,3,5-Triazines Compounds as Ultraviolet Rays Absorber Based on Time-Dependent Density Functional Calculations and three-Dimensional Quantitative Structure-Property Relationship

A series of 1,3,5-triazines were synthesized and their UV absorption properties were tested. The computational chemistry methods were used to construct quantitative structure-property relationship (QSPR), which was used to computer aided design of new 1,3,5-triazines ultraviolet rays absorber compounds. The experimental UV absorption data are in good agreement with those predicted data using the Time-dependent density functional theory (TD-DFT) [B3LYP/6–311 + G(d,p)]. A suitable forecasting model (R > 0.8, P 0.0001) was revealed. Predictive three-dimensional quantitative structure-property relationship (3D-QSPR) model was established using multifit molecular alignment rule of Sybyl program, which conclusion is consistent with the TD-DFT calculation. The exceptional photostability mechanism of such ultraviolet rays absorber compounds was studied and confirmed as principally banked upon their ability to undergo excited-state deactivation via an ultrafast excited-state proton transfer (ESIPT). The intramolecular hydrogen bond (IMHB) of 1,3,5-triazines compounds is the basis for the excited state proton transfer, which was explored by IR spectroscopy, UV spectra, structural and energetic aspects of different conformers and frontier molecular orbitals analysis.

The umpolung of substituent effect in nucleophilic aromatic substitution. A new approach to the synthesis of N,N-disubstituted melamines (triazine triskelions) under mild reaction conditions

By the umpolung of substituent effect 1,3,5-triazines substituted with three dialkylamino groups were prepared under mild reaction conditions by treatment of cyanuric chloride with tertiary amines. Quaternary N-triazinylammonium salts were identified as reactive intermediates activating the triazine ring and strongly promoting the persubstitution of all chlorine atoms. The final degradation of intermediate N-triazinylammonium chlorides proceeded at room temperature or in boiling dichloromethane spontaneously within irreversible evolution of appropriate chloroalkane.

A practical and easy synthesis of 2,4,6-trisubstituted-s-triazines

Triflic anhydride was found to be efficient for the cyclotrimerization of dialkylcyanamides under mild conditions. The same reaction can be applied to aryl nitriles and thiocyanates.

A convenient method for the preparation of some new derivatives of 1,3,5-s-triazine under solvent free condition

Nucleophilic reactions on cyanuric chloride were carried out under solvent free conditions to give 1,3,5-s-triazine derivatives with excellent yields.

Reaction of disubstituted cyanamides with formamides under high pressure

High pressure-assisted co-cyclization of disubstituted cyanamides with formamide or monosubstituted formamides gave 2-amino- or 2-monosubstituted amino-4,6-bis(disubstituted amino)-1,3,5-triazines in one pot.

4,6-Bis- and 2,4,6-tris-(N,N-dialkylamino)-s-triazines: synthesis, NMR spectra and restricted rotations

Syntheses of various symmetrically and non-symmetrically trisubstituted trazines are reported.Dynamic NMR (1H and 13C) experiments demonstrate that 2,4,6-tris(dialkylamino)-s-triazines show correlated rotations of the alkyl groups in the dialkylamino moieties.Unsymmetrical 2-chloro, 2-alkoxy- and 2-aryloxy-4,6-bis(di-n-alkylamino)-s-triazines display two non-equivalent n-alkyl groups, due to the restricted rotation around the Ar-N bonds.