212571-01-2

Usage

InChI:InChI=1/C9H7NO2S/c1-12-9(11)6-4-8-7(10-5-6)2-3-13-8/h2-5H,1H3

Upstream product

• 17721-06-1 3-aminothiophene 
• 7424-91-1 methyl 3,3-dimethoxypropionate 
• 75877-27-9 (E)-3-(3-Amino-thiophen-2-yl)-acrylic acid methyl ester 
• 57597-62-3 3,3-dimethoxypropionitrile 
• 98-03-3 thiophene-2-carbaldehyde 
• 124957-34-2 methyl 2-(hydroxy(2-thienyl)methyl)acrylate 
• 124957-38-6 methyl 2-[acetoxy(thiophen-2-yl)methyl]acrylate 
• 73410-75-0 (E)-methyl 2-(aminomethyl)-3-(thiophen-2-yl)acrylate 
• 212570-86-0 methyl 3-(3-t-butoxycarbonylaminothien-2-yl)propenoate 

Relevant academic research and scientific papers

Iodine-mediated intramolecular electrophilic aromatic cyclization in allylamines: A general route to synthesis of quinolines, pyrazolo[4,3-b] pyridines, and thieno[3,2-b]pyridines

An unprecedented synthesis of aromatic ring annulated pyridines from suitably substituted primary allylamines via intramolecular electrophilic aromatic cyclization mediated by molecular iodine under mild conditions is described.

α-vinylation of β-aminothiophene derivatives. Synthesis of 6- functionalized thieno[3,2-b]pyridines

The acid-catalyzed reductive α-alkylation of β-aminothiophenes was applied to the N-(thien-3-yl)acetamide and alkyl N-(thien-3-yl)carbamates. Without reduction, β-amino α-vinylthiophenes were obtained when α-branched aldehydes were used. β-(3-Aminothien-2-yl)α,β-unsaturated ketones, esters and nitriles were also prepared from the corresponding α-functionalized acetals. These amines are intermediates in the formation of thieno[3,2- b]pyridines bearing a functional group at the β-position of the pyridine ring.