212610-19-0Relevant academic research and scientific papers
Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors
Wang, Qiang,Xu, Fuming,Mou, Jiajia,Zhang, Jian,Shang, Luqing,Luan, Yepeng,Yuan, Yumei,Liu, Yingzi,Li, Minyong,Fang, Hao,Wang, Binghe,Xu, Wenfang
, p. 847 - 853 (2010)
A novel class of L-lysine derivatives as aminopeptidase N (APN) inhibitors was designed and synthesized. Activity evaluation showed that compound C7 (IC50 = 9.6 ± 1.3 μM) and C20 (IC50 = 13.6 ± 1.9 μM) were equivalent to the positive control Bestatin (IC50 = 11.3 ± 1.6 μM).
