212621-45-9

Basic information

• Product Name: 4-benzylsulfanyl-5-(2H-tetrazol-5-yl)-2-thiophen-2-yl-pyrimidine
• CAS NO: 212621-45-9
• Molecular Weight: 352.443
• Mol File: 212621-45-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzylsulfanyl-5-(2H-tetrazol-5-yl)-2-thiophen-2-yl-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzylsulfanyl-5-(2H-tetrazol-5-yl)-2-thiophen-2-yl-pyrimidine(212621-45-9)
• EPA Substance Registry System: 4-benzylsulfanyl-5-(2H-tetrazol-5-yl)-2-thiophen-2-yl-pyrimidine(212621-45-9)

Safety Data

• Hazardous Substances Data: 212621-45-9(Hazardous Substances Data)

Upstream product

• 212621-39-1 ethyl 4-(benzylthio)-2-(2'-thienyl)pyrimidine-5-carboxylate 
• 212621-69-7 4-(benzylthio)-2-(2'-thienyl)-pyrimidine-5-carboxylic acid 
• 212621-70-0 4-(benzylthio)-2-(2'-thienyl)-pyrimidine-5-carboxamide 
• 188937-37-3 4-hydroxy-2-thiophen-2-yl-pyrimidine-5-carboxylic acid ethyl ester 
• 188937-40-8 ethyl 4-chloro-2-(2'-thienyl)pyrimidine-5-carboxylate 
• 54610-75-2 2-thiophenecarboxamidine 
• 212621-35-7 4-(benzylthio)-5-cyano-2-(2'-thienyl)pyrimidine 

Downstream Products

• 212621-72-2 5-(2-methyl-2H-tetrazol-5-yl)-4-phenylmethanesulfonyl-2-thiophen-2-yl-pyrimidine 
• 212621-46-0 4-benzylsulfanyl-5-(2-methyl-2H-tetrazol-5-yl)-2-thiophen-2-yl-pyrimidine 

Relevant articles and documents

Novel inhibitors of AP-1 and NF-κB mediated gene expression: Structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate

In an effort to identify novel inhibitors of AP-1 and NF-κB mediated transcriptional activation, several analogues of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carb oxylate (1) were synthesized and tested in two in vitro assays. The 2-(2'-thienyl) substituted compound (11) was identified as the most potent in this series. (C) 2000 Elsevier Science Ltd. All rights reserved.