212650-43-6

Basic information

• Product Name: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER
• Synonyms: 4-N-BOC-3-MORPHOLINECARBOXYLIC ACID;4-(TERT-BUTOXYCARBONYL)MORPHOLINE-3-CARBOXYLIC ACID;MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER;(S)-Morpholine-3,4-dicarboxylic acid 4-tert-butyl;Morpholine-3,4-dicarboxylic acid 4-tert-butyl;N-Boc-Morpholine-2-carboxylic acid;N-Boc-morpholine-3-carboxylic acid;4-Boc-3-morpholinecarboxylic acid
• CAS NO: 212650-43-6
• Molecular Formula: C₁₀H₁₇NO₅
• Molecular Weight: 231.25
• Product Categories: pharmacetical
• Mol File: 212650-43-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 369℃
• Flash Point: 177℃
• Appearance: /
• Density: 1.230
• Vapor Pressure: 1.8E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 3.53±0.20(Predicted)
• CAS DataBase Reference: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER(212650-43-6)
• EPA Substance Registry System: MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER(212650-43-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-51-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 212650-43-6(Hazardous Substances Data)

Usage

General Description

Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester is rarely natural and primarily synthesized in laboratories for its potential uses in the chemical industry. Its detailed chemical composition and properties are not widely researched; however, like other esters, it's expected to have characteristics including potential reactivity with water and various acids and stability under normal temperatures and pressures. It could be harmful if ingested or gotten in eyes, or if it comes into contact with the skin. Detailed toxicity data is lacking.

InChI:InChI=1/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/p-1/t7-/m0/s1

Upstream product

• 66937-99-3 morpholine-3-carboxylic acid hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 212650-45-8 morpholine-3,4-dicarboxylic acid 4-tert-butyl ester 3-methyl ester 
• 126264-49-1 methyl 3-morpholine-carboxylate 
• 473923-56-7 tert-Butyl 3-(hydroxymethyl)-4-morpholinecarboxylate 
• 77873-76-8 morpholine-3-carboxylic acid 

Downstream Products

• 1398396-60-5 N-((R)-1-(naphthalen-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)morpholine-3-carboxamide 
• 1398396-78-5 N-((R)-1-(naphthalen-1-yl)ethyl)-4-(3-(trifluoromethyl)benzyl)morpholine-3-carboxamide 
• 1398494-05-7 (1R)-1-(naphthalen-1-yl)-N-((4-phenylmorpholin-3-yl)methyl)ethanamine 
• 1398494-06-8 (1R)-1-(naphthalen-1-yl)-N-((4-phenylmorpholin-3-yl)methyl)ethanamine 
• 1398236-15-1 (1R)-1-(naphthalen-1-yl)-N-((4-(3-trifluoromethylphenyl)morpholin-3-yl)methyl)ethanamine 
• 1398236-06-0 N-((R)-1-(naphthalen-1-yl)ethyl)-4-(3-(trifluoromethyl)phenyl)morpholine-3-carboxamide 
• 1398241-18-3 (1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine 
• 1398241-09-2 (1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine 
• 1398363-56-8 (3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)morpholino)(phenyl)methanone 
• 1398363-48-8 (3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)morpholino)(phenyl)methanone 
• 1398397-93-7 3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-N-phenylmorpholine-4-carboxamide 
• 1398397-88-0 3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-N-phenylmorpholine-4-carboxamide 
• 1398396-53-6 N-((R)-1-(naphthalen-1-yl)ethyl)-4-phenylmorpholine-3-carboxamide 
• 1101987-05-6 N,N-dimethylmorpholine-3-carboxamide 

Relevant articles and documents

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling

The direct union of primary, secondary, and tertiary carboxylic acids with a chiral glyoxylate-derived sulfinimine provides rapid access into a variety of enantiomerically pure α-amino acids (>85 examples). Characterized by operational simplicity, this radical-based reaction enables the modular assembly of exotic α-amino acids, including both unprecedented structures and those of established industrial value. The described method performs well in high-throughput library synthesis, and has already been implemented in three distinct medicinal chemistry campaigns.

Synthesis of 3-oxadiazolyl/triazolyl morpholines: Novel scaffolds for drug discovery

Synthesis of isomeric 3-oxadiazolyl/triazolyl morpholines was performed based on a common intermediate on the gram scale. The target compounds were designed as novel scaffolds for the medicinal chemistry. The key reaction was an electrochemical CH-oxidati

SUBSTITUTED MORPHOLINES AS MODULATORS FOR THE CALCIUM SENSING RECEPTOR

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).