212695-45-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
6-(Trifluoromethoxy)quinoline is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, leveraging its unique chemical structure to create novel compounds with potential therapeutic or pesticidal properties.
Used in Materials Research:
TFMOQ is utilized in materials research as a component in the development of new materials with specific properties, such as those needed for high-performance applications.
Used in Organic Light-Emitting Diodes (OLEDs):
6-(Trifluoromethoxy)quinoline is used as an electron-transporting material in the fabrication of OLEDs, contributing to the efficiency and performance of these devices.
Used in Electronic Devices:
TFMOQ's electron transporting properties make it a candidate for use in other electronic devices that require materials with specific electronic characteristics.
Used in Antimicrobial Applications:
6-(Trifluoromethoxy)quinoline is studied for its antimicrobial properties, potentially serving as an active ingredient in products designed to inhibit the growth of microorganisms.
Used in Anti-Inflammatory Applications:
TFMOQ has been investigated for its anti-inflammatory properties, suggesting a possible use in the development of treatments for conditions characterized by inflammation.
These applications highlight the versatility of 6-(Trifluoromethoxy)quinoline across different industries, underscoring its importance in the development of innovative products and technologies.

Upstream product

• 461-82-5 4-(trifluoromethoxy)aniline 
• 7664-93-9 sulfuric acid 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 96898-10-1 tris(dimethylamino)sulfonium trifluoromethoxide 

Downstream Products

• 1352443-11-8 2-Bromo-6-(trifluoromethoxy)quinoline 

Relevant academic research and scientific papers

Sequential Xanthalation and O-Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers

Molecules containing trifluoromethoxyaryl groups are of interest in pharmaceutical, agrochemical, and materials science research, due to their unique physical and electronic properties. Many of the known methods to synthesize aryl trifluoromethyl ethers require harsh reagents and highly controlled reaction conditions and rarely occur when heteroaromatic units are present. The two-step O-trifluoromethylation of phenols via aryl xanthates is one such method that suffers from these drawbacks. Herein, we report a method for the synthesis of aryl trifluoromethyl ethers from phenols by the facile conversion of the phenol to the corresponding aryl and heteroaryl xanthates with newly synthesized imidazolium methylthiocarbonothioyl salts and conversion of these xanthates to the trifluoromethyl ethers under mild reaction conditions.

METALLOENZYME INHIBITOR COMPOUNDS

The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Silver-mediated trifluoromethoxylation of aryl stannanes and arylboronic acids

A silver-mediated cross-coupling of trifluoromethoxide with aryl stannanes and arylboronic acids to give aryl trifluoromethyl ethers is reported. This is the first report of a transition-metal-mediated Caryl-OCF3 bond formation.

ANTIDEPRESSANT ARYLPIPERAZINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS

Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

Thiazolo[5,4,3-ij]quinolines, preparation and medicines containing the same

Compounds of formula (I): their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof, processes for preparing them and the medicaments containing them are discussed.