212764-84-6

Upstream product

• 212764-79-9 methyl (2R,3S)-2-methoxy-3-phenyl-3-<(S)-methylbenzylamino>propanoate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 38870-89-2 Methoxyacetyl chloride 
• 3129-98-4 (S)-N-benzylidene(1-phenylethylamine) 
• 69350-13-6 N-benzylidene-(S)-α-methylbenzylamine 

Downstream Products

• 154306-81-7 (3R,4S)-3-hydroxy-4-phenyl-1-<(S)-methylbenzyl>azetidin-2-one 

Relevant academic research and scientific papers

Practical synthesis of taxol side chain

Practical large scale synthesis of N-benzoyl-(2R,3S)-phenylisoserine methyl ester of the Taxol side chain has been attained from the coupling of chiral imine of N-[(S)-methylbenzyl]benzaldimine with (Z)-α-methoxy trimethylsilyl ketene acetal followed by the sequential reactions of lactamization, demethylation, methanolysis and N-benzoylation.

An investigation towards the diastereoselective synthesis of 3-acetoxy/methoxy/phthalimido-β-lactams using chiral imines

The efficient diastereoselective synthesis of 3-acetoxy/methoxy/phthalimido-β-lactams 2/2′, 3/3′ and 4/4′ respectively was performed using chiral imines 1 obtained from chiral amines. Factors (solvent, temperature, substituent, steric bulk) influencing th

Asymmetric synthesis of β-amino-α-hydroxy acids through Lewis acid-mediated addition of ketene acetal to imines

Asymmetric synthesis of β-amino-α-hydroxy acids, key components of medicinally important molecules including Paclitaxel, KRI-1314, amastatin, and microginin, has been attained from the aldimine coupling of chiral imines N-alkylidene-(S)- or (R)-α-methylbenzylamine with (Z)-α-methoxyketene methyltrimethylsilyl acetal, followed by demethylation, hydrogenolysis, and hydrolysis.