212776-45-9Relevant academic research and scientific papers
New enantiodivergent procedure for the syntheses of chiral α- substituted serines from α-alkyl-α-aminomalonates utilizing enzymatic hydrolysis
Sano, Shigeki,Hayashi, Kazuhiko,Miwa, Toshio,Ishii, Takahiro,Fujii, Michiho,Mima, Hiromi,Nagao, Yoshimitsu
, p. 5571 - 5574 (2007/10/03)
Porcine liver esterase (PLE)- or rabbit liver esterase (RLE)-catalyzed hydrolysis of the pro-S ester group of diethyl α-alkyl-α- (benzyloxycarbonylamino)malonates 2a-c afforded (R)-ethyl α-alkyl-α- (benzyloxycarbonylamino)malonates 3a-c each in excellent enantiomeric excess. Enantiodivergent reductions of these acid esters 3a-c readily furnished both the corresponding enantiomeric α-substituted serines (R)- and (S)-5a-c.
