212776-53-9

Upstream product

• 80904-75-2 4-hydroxymethyl-5H-furan-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 205043-35-2 4-(tert-butyldimethylsilanyloxy)-3-(tert-butyldimethylsilanyloxymethyl)but-2-enoic acid ethyl ester 

Downstream Products

• 328386-16-9 (+/-)-4-(tert-butyldiphenylsilyloxymethyl)-4H,5H-dihydrofuran-2-one 
• 212776-55-1 Acetic acid 4-azido-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl ester 

Relevant academic research and scientific papers

Total synthesis of (±)-Iso-d4T as potential antiviral agent

(±)-Iso-d4T which may act as a bioisostere of d4T was synthesized from 1,3-dihydroxyacetone using phenyl selenenium chemistry as a key step.

Structure-activity relationships of apio nucleosides as potential antiviral agents

Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.

Synthesis and antiviral activity of apio dideoxy nucleosides with azido or amino substituent

Novel apio dideoxynucleosides with azido or amino substituent were synthesized starting from 1,3-dihydroxyacetone utilizing an acid-catalyzed 1,4conjugated addition as a key step and evaluated for antiviral activity. Unfortunately, they were found to be neither active against HIV-1, HSV-1,2 and poliovirus nor toxic.