212890-97-6

Upstream product

• 212890-94-3 3,3-dimethyl-5-(2-oxanyloxymethyl)pyrrolidin-2-one 
• 156088-46-9 (5S)-3,3-dimethyl-5-hydroxymethylpyrrolidin-2-one 
• 1000894-75-6 C₁₄H₁₇NO₂ 
• 212890-96-5 3,3-dimethyl-5-(2-oxanyloxymethyl)-1-benzylpyrrolidin-2-one 

Downstream Products

• 1000894-81-4 C₁₄H₂₁NO 
• 212890-98-7 (S)-(+)-3,3-dimethyl-5-[((4-methylphenyl)sulfonyloxy)methyl]-1-benzylpyrrolidin-2-one 

Relevant academic research and scientific papers

Substituted Piperidines that Increase P53 Activity and the Uses Thereof

In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

An external chiral amidophosphine ligand for asymmetric conjugate addition of organocopper

Two types of external, chiral amidophosphine ligands, 1-5, were prepared. Examination of their behavior in an asymmetric conjugate addition reaction of organocuprate revealed the possibility for steric tuning to realize high selectivity.