156088-46-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique chiral center and reactivity allow for the creation of complex molecules with specific biological activities.
Used in Adhesives, Coatings, and Polymers Production:
2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)is used in the production of adhesives, coatings, and polymers due to its reactivity and versatility. Its ability to form stable bonds with other molecules contributes to the development of high-performance materials with various applications.
Used as a Solvent in Chemical Reactions and Processes:
2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)is used as a solvent for a wide range of chemical reactions and processes. Its ability to dissolve various substances and facilitate chemical transformations makes it a valuable component in the synthesis of different compounds and materials.

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 156088-43-6 (+)-(S)-3,3-dimethyl-5-[(triphenylmethoxy)methyl]pyrrolidin-2-one 
• 443984-28-9 (S)-(N-benzyloxycarbonyl)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol 
• 156088-48-1 (5S)-1-(2,2-dimethylpropionyl)-3,3-dimethyl-5-trityloxymethylpyrrolidin-2-one 
• 212890-84-1 (S)-2-[(Diphenylphosphanyl)-methyl]-4,4-dimethyl-pyrrolidine 
• 212890-98-7 (S)-(+)-3,3-dimethyl-5-[((4-methylphenyl)sulfonyloxy)methyl]-1-benzylpyrrolidin-2-one 
• 212890-96-5 3,3-dimethyl-5-(2-oxanyloxymethyl)-1-benzylpyrrolidin-2-one 
• 212890-97-6 (S)-(+)-5-(hydroxymethyl)-3,3-dimethyl-1-benzylpyrrolidin-2-one 
• 184699-47-6 (S)-(-)-tert-butyl 4,4-dimethyl-2-[((4-methylphenyl)sulfonyloxy)methyl]pyrrolidinecarboxylate 
• 212890-87-4 (S)-(-)-tert-butyl 2-[(diphenylphosphino)methyl]-4,4-dimethylpyrrolidinecarboxylate 
• 184699-46-5 (S)-(+)-1,3,3-trimethyl-5-[((4-methylphenyl)sulfonyloxy)methyl]pyrrolidin-2-one 
• 212890-86-3 (S)-(-)-tert-butyl 2-(hydroxymethyl)-4,4-dimethylpyrrolidinecarboxylate 
• 260782-06-7 (S)-5-(Dicyclohexyl-phosphinoylmethyl)-3,3-dimethyl-pyrrolidin-2-one 
• 260781-95-1 (+)-(S)-5-[(4-diphenylphosphino)methyl]-3,3-dimethylpyrrolidin-2-one 
• 473808-17-2 (S)-3,3-Dimethyl-1-(3-phenyl-propionyl)-5-trityloxymethyl-pyrrolidin-2-one 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted pyridinyl-pyrimidines of formula 1 wherein ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O, wherein R1, R2, R4, R3, R5 and R6 are defined as in claim 1 and wherein ring A is further optionally substituted by one or two further substituents and the pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates and solvates of the aforementioned compounds.

Synthesis and utility of the 3,3-dimethyl-5-substituted-2-pyrrolidinone 'Quat' chiral auxiliary

The synthesis and utility of the 3,3-dimethyl-5-substituted-2-pyrrolidinone 'Quat' chiral auxiliary in stereoselective enolate reactions of attached N-acyl side chains combined with the mild and non-racemising conditions required for the ultimate removal of the chiral side chain is described.

Synthesis of 5-substituted-3,3-dimethyl-2-pyrrolidinones: "Quat" chiral auxiliaries

The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, "quats", from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with LiOH in THF-water at 20°C.