212892-48-3

Upstream product

• 205653-01-6 {(R)-1-[(4R,5S)-5-(1-Hydroxy-allyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-trityloxy-ethyl}-carbamic acid tert-butyl ester 
• 127298-73-1 (3R,4R,5R)-3,4-Dihydroxy-2-oxo-5-trityloxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 124665-82-3 (S)-2-Oxo-5-trityloxymethyl-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 212892-09-6 {(R)-1-[(4R,5S)-5-((R)-1,2-Dihydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-trityloxy-ethyl}-carbamic acid tert-butyl ester 
• 126199-70-0 [(R)-1-((4R,5R)-5-Acryloyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-trityloxy-ethyl]-carbamic acid tert-butyl ester 
• 124665-84-5 (3R,4R,5R)-1-(tert-butoxycarbonyl)-3,4-isopropylidenedioxy-5-trityloxymethyl-2-pyrrolidinone 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 212892-46-1 ((R)-1-{(4R,5S)-5-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-trityloxy-ethyl)-carbamic acid tert-butyl ester 
• 212892-10-9 {(R)-1-[(4R,5S)-5-((S)-1,2-Dihydroxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-trityloxy-ethyl}-carbamic acid tert-butyl ester 

Downstream Products

• 212892-52-9 (2R,3R,4S,5R)-N-tert-butoxycarbonyl-3,4-isopropylidenedioxy-2-trityloxymethyl-5-hydroxymethylpyrrolidine 
• 212892-21-2 (2R,3R,4S,5R)-N-tert-butoxycarbonyl-3,4-isopropylidenedioxy-2-trityloxymethyl-5-((1R)-1-hydroxy-3-butenyl)pyrrolidine 
• 212892-15-4 (2R,3R,4S,5R)-N-tert-butoxycarbonyl-3,4-isopropylidenedioxy-2-trityloxymethyl-5-((1S)-1-hydroxy-3-butenyl)pyrrolidine 
• 142406-04-0 (2R,3R,4S,5R)-N-benzyl-3,4-isopropylidenedioxy-2-trityloxymethyl-5-((1S)-1-methoxymethyloxy-3-butenyl)pyrrolidine 
• 142406-04-0 (3aS,4R,6R,6aR)-5-Benzyl-4-((R)-1-methoxymethoxy-but-3-enyl)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole 
• 212892-17-6 (2R,3R,4S,5R)-N-tert-butoxycarbonyl-3,4-isopropylidenedioxy-2-trityloxymethyl-5-((1S)-1-methoxymethyloxy-3-butenyl)pyrrolidine 
• 212892-24-5 (3aS,4R,6R,6aR)-4-((R)-1-Methoxymethoxy-but-3-enyl)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester 
• 212892-28-9 (2R,3R,4S,5R)-N-benzyl-3,4-isopropylidenedioxy-2-trityloxymethyl-5-((1S)-1-methoxymethyloxy-3-hydroxypropanyl)pyrrolidine 
• 212892-12-1 tert-butyl (3aS,4R,6R,6aR)-4-{{[(tert-butyl)dimethylsilyl]oxy}methyl}tetrahydro-2,2-dimethyl-6-[(trityloxy)methyl]-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate 

Relevant academic research and scientific papers

Stereoselective synthesis of alexine stereoisomers from (S)- pyroglutamic acid

Four stereoisomers of alexine (1,7a-diepialexine (1a), 1,7,7a- triepialexine (1b), 1-epialexine (30a), and 1,7-diepialexine (30b)), the polyhydroxylaled pyrrolizidine alkaloid, were synthesized from (S)- pyroglutamic acid derivative (6).

Stereocontrolled synthesis of 1,7a-diepialexine

(2R,5R)-Dihydroxymethyl-(3R,4S)-dihydroxypyrrolidine derivative 15, 1,7a-diepialexine 1, and 1,7,7a-triepialexine 2 have been synthesized from (S)-pyroglutamic acid derivative 4.