2129-61-5

Upstream product

• 17366-51-7 (Z)-2-Acetyl-1-<(3,4-dimethoxyphenyl)methylene>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 6957-27-3 3,4-dihydropapaverine 
• 139-76-4 N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide 

Downstream Products

• 340829-05-2 N-(2-{2-[2-(3,4-dimethoxy-phenyl)-1-hydroxy-ethyl]-4,5-dimethoxy-phenyl}-ethyl)-acetamide 
• 339067-73-1 N-(2-{2-[(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dimethoxy-phenyl}-ethyl)-acetamide 
• 198981-34-9 2-(2-acetamidoethyl)-2'-nitro-4,4',5,5'-tetramethoxydeoxybenzoin 
• 340829-13-2 5-[2-(3,4-dimethoxy-phenyl)-vinyl]-7,8-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester 
• 339067-74-2 N-(2-{2-[2-(2-bromo-4,5-dimethoxyphenyl)-1-methoxyethyl]-4,5-dimethoxyphenyl}ethyl)acetamide 
• 340829-11-0 5-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-7,8-dimethoxy-1-methyl-3,4-dihydroisoquinoline 
• 340829-12-1 5-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-7,8-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 340829-03-0 N-(2-{2-[2-(3,4-dimethoxy-phenyl)-vinyl]-4,5-dimethoxy-phenyl}-ethyl)-acetamide 

Relevant academic research and scientific papers

Total syntheses of 1-methyl-1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines involving free radical cyclizations induced by tributyltin(IV) hydride

We describe two total syntheses of 1-methyl-1,2,3,4-tetrahydronaphtho[1,2-f]isoquinolines based on free radical cyclization. One of them includes the cyclization of N-{2-[2-(2-bromophenyl)-1-methoxyethyl]phenylethyl}acetamides and subsequent transformation of the resulting N-[2-(10-methoxy-9,10-dihydro-1-phenanthryl)ethyl]acetamides. The second is based on the known cyclization of 1-(2-bromobenzyl)isochroman-3-ones to 4,5,6a,7-tetrahydrodibenzo[de,g]chroman-3-ones followed by transformation of the resulting 2-(1-phenanthryl)acetamides.

Piperazine derivatives useful as calmodolin inhibitors

A compound represented by formula (I): wherein Q represents an aryl group, a heterocyclic group, a diarylmethyl group, an aralkyl group composed of an aryl group and an alkylene group, an alkyl group or a cycloalkyl group, in which the aryl group, heterocyclic group, and the aryl moiety of the diarylmethyl group and aralkyl group may be substituted with one or more substituents; R represents a bicyclic, substituted, nitrogen-containing heterocyclic group or a substituted phenyl group, in which the nitrogen-containing heterocyclic group is composed of a 5-membered, substituted, aromatic or saturated ring containing one or two nitrogen atoms and a 6-membered ring; and Z represents an alkylene group, an alkenylene group, an alkylene group, a carbonyl group, an alkylene group containing a carbonyl group or an oxalyl group,or a salt thereof. The compound has calmodulin inhibitory activity and is useful as a treating agent for diseases in the circulatory organs or in the cerebral region which are caused by excessive activation of calmodulin.