212909-84-7

Basic information

• Product Name: tert-Butyl-{(1R,2R)-2-[4-fluoro-2-((Z)-propenyl)-phenoxy]-cyclohept-3-enyloxy}-dimethyl-silane
• Synonyms: tert-Butyl-{(1R,2R)-2-[4-fluoro-2-((Z)-propenyl)-phenoxy]-cyclohept-3-enyloxy}-dimethyl-silane
• CAS NO: 212909-84-7
• Molecular Weight: 376.587
• Mol File: 212909-84-7.mol

Chemical Properties

• CAS DataBase Reference: tert-Butyl-{(1R,2R)-2-[4-fluoro-2-((Z)-propenyl)-phenoxy]-cyclohept-3-enyloxy}-dimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl-{(1R,2R)-2-[4-fluoro-2-((Z)-propenyl)-phenoxy]-cyclohept-3-enyloxy}-dimethyl-silane(212909-84-7)
• EPA Substance Registry System: tert-Butyl-{(1R,2R)-2-[4-fluoro-2-((Z)-propenyl)-phenoxy]-cyclohept-3-enyloxy}-dimethyl-silane(212909-84-7)

Safety Data

• Hazardous Substances Data: 212909-84-7(Hazardous Substances Data)

Upstream product

• 496-69-5 2-bromo-4-fluoro-phenol 
• 212909-78-9 2-propenyl-4-fluorophenol 
• 347-54-6 5-fluoro-2-hydroxybenzaldehyde 
• 876938-53-3 Cyclohepta-1,3-diene 
• 371-41-5 4-Fluorophenol 

Downstream Products

• 152520-56-4 d-nebivolol hydrochloride 

Relevant articles and documents

Zr-catalyzed kinetic resolution of allylic ethers and mo-catalyzed chromene formation in synthesis. Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol

The first enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol (3) is described. The synthesis includes the efficient (EBTHI)Zr-catalyzed kinetic resolutions of cycloheptenyl styrenyl ethers 8 and 16, which are subsequently t