347-54-6

Usage

Uses

Used in Chemical Synthesis:
5-Fluorosalicylaldehyde is used as a key intermediate for the synthesis of complex organic molecules, such as manganese (III) complexes, enantiopure chromanes, and various other organic compounds. Its unique structure allows for the creation of a wide range of molecules with diverse applications.
Used in Pharmaceutical Industry:
5-Fluorosalicylaldehyde is used as a building block for the development of new pharmaceutical compounds. Its role in synthesizing various organic molecules makes it a valuable asset in the design and production of novel drugs with potential therapeutic applications.
Used in Material Science:
In the field of material science, 5-Fluorosalicylaldehyde can be utilized in the synthesis of advanced materials with specific properties. Its ability to form complexes and contribute to the development of new compounds makes it a promising candidate for creating materials with tailored characteristics for various applications.
Used in Research and Development:
5-Fluorosalicylaldehyde is used as a research compound for exploring new chemical reactions and understanding the behavior of different molecules. Its unique properties make it an essential tool in the hands of chemists and researchers working on the development of new chemical processes and applications.

InChI:InChI=1/C7H6F3NS/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4H,11H2

Upstream product

• 371-41-5 4-Fluorophenol 
• 67-66-3 chloroform 
• 50-00-0 formaldehyd 
• 100-97-0 hexamethylenetetramine 
• 496-69-5 2-bromo-4-fluoro-phenol 
• 68-12-2 N,N-dimethyl-formamide 
• 2357-33-7 5-fluoro-2-hydroxy-benzyl alcohol 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 19415-51-1 5-fluoro-2-methoxybenzaldehyde 
• 452-72-2 4-fluoro-2-methylphenol 
• 91407-40-8 5-fluoro-2-hydroxybenzaldehyde oxime 
• 76-05-1 trifluoroacetic acid 
• 1998-90-9 2-acetoxy-5-fluoro benzyl acetate 

Downstream Products

• 366-58-5 5-fluoro-2-hydroxy-benzaldehyde phenylhydrazone 
• 100-02-7 4-nitro-phenol 
• 184432-11-9 2-(cyclohex-2-enyloxy)-5-fluorobenzaldehyde 
• 1054643-58-1 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-(4-fluoro-2-formyl-phenoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 345-16-4 5-fluoro-2-hydroxybenzoic acid 
• 312314-37-7 2-(benzyloxy)-5-fluorobenzaldehyde 
• 496043-35-7 2-(5'-fluoro-2'-hydroxyphenyl)-1,3-dithiane 
• 612500-22-8 2-(benzylamino-methyl)-4-fluoro-phenol 
• 367-32-8 4-fluoropyrocatechol 
• 863288-39-5 methyl (E)-3-(5-fluoro-2-hydroxyphenyl)acrylate 
• 875925-97-6 (8-fluoro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-phenyl-amine 
• 875925-94-3 benzyl-(8-fluoro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine 
• 875926-02-6 (3-bromo-phenyl)-(8-fluoro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine 
• 875926-04-8 (3-chloro-4-fluoro-phenyl)-(8-fluoro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine 

Relevant academic research and scientific papers

Benzimidazole Based ‘Turn on’ Fluorescent Chemodosimeter for Zinc Ions in Mixed Aqueous Medium

Benzimidazole based compound 3 is designed and synthesized. The compound 3 is evaluated as fluorogenic sensor for metal ions in mixed aqueous solutions. Among all the metal ions tested, the compound 3 selectively senses Zn2+ ions. The imine bond of 3 gets cleaved by Zn2+ ions. Thus, 3 behave as ‘turn on’ fluorescent chemodosimeter for Zn2+ ions with limit of detction in micromolar range. Furthurmore, we demonstated that 3 can detect Zn2+ ions in cells of Allium cepa. [Figure not available: see fulltext.]

Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: Access to the synthesis of chromeno[4,3-: B] pyrroles

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.

Synthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light

Synthesis of new Schiff's base Zn-complexes for photo-oxidation of methyl arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of methyl arenes which are converted into its respective aldehydes with moderate yields under visible light irradiation. The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the methyl groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of methyl arenes is reported under visible-light-driven conditions.

Effects of Substituents on Metastable-State Photoacids: Design, Synthesis, and Evaluation of their Photochemical Properties

Recently, metastable-state photoacids have been widely used to control proton transfer in numerous chemical and biological processes as well as applications with visible light. Generally, substituents have a great influence on the photochemical properties of molecules, which will further affect their applications. Yet, the effects of substituents on metastable-state photoacids have not been studied systematically. In this work, 16 metastable-state photoacid derivatives were designed and synthesized on the basis of substituents having a large range of σ–π electron–donor–acceptor capabilities. The effects of substituents on the color display [or maximum absorption band(s)], solubility, pKa values, dark/photoacidity, photosensitivity, and relaxation kinetic(s) were investigated in detail. This study will be helpful for the targeted design and synthesis of promising photoacids and the application of their photocontrolled proton-release processes in functional materials/devices.

Thiocyanate radical mediated dehydration of aldoximes with visible light and air

We developed a new means of activating aldoximes by an in situ generated thiocyanate radical from ammonium thiocyanate and molecular oxygen at room temperature. With a catalytic amount of organic dye aizenuranine as the photocatalyst, the dehydration of aldoximes proceeds smoothly under visible light irradiation, providing a simple to handle, excellent functional group tolerance, and metal-free protocol for a wide range of nitriles.

Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines

Phosphine-catalyzed [3+2] annulation of β-sulfonamido-substituted enones and sulfamate-derived cyclic imines has been developed, giving a series of imidazoline derivatives in moderate to excellent yields with good to excellent diastereoselectivities. A scale-up reaction worked well under mild reaction conditions. A possible mechanism was proposed on the basis of the results obtained.

C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF

This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor. The C-aryl glycoside derivatives of this invention provides a new direction for the study of SGLT inhibitors.

Efficient synthesis of chiral benzofuryl β-amino alcohols via a catalytic asymmetric Henry reaction

Chiral β-amino alcohol ligands were found effective for the copper(ii)-catalyzed asymmetric Henry reaction of benzofuran-2-carbaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl β-nitro alcohols with satisfactory enantioselectivities (up to 98% ee). Using this catalytic protocol, bioactive (S)-benzofuryl β-amino alcohols could be conveniently prepared in short steps.

Enantioselective Synthesis of 6,6-Disubstituted Pentafulvenes Containing a Chiral Pendant Hydroxy Group

Simple enantioselective synthesis of 6,6-disubstituted pentafulvenes bearing chiral pendant hydroxy groups are attained by cascade reactivity using commercially available proline-based organocatalysts. Condensation of cyclopentadiene with the acetyl function of a 1,2-formylacetophenone, followed by cyclization of a resulting fulvene-stabilized carbanion with the formyl group, generates bicyclic chiral alcohols with initial er values up to 94:6. Exceptional enantio-enrichment of the resultant alcohols results upon crystallization—even near racemic samples spontaneously de-racemize. This enables new families of substituted cyclopentadienes that are both enantiomerically and diastereomerically pure to be rapidly attained.

Phosphine-Catalyzed [4 + 2] Annulation of Allenoate with Sulfamate-Derived Cyclic Imines: A Reaction Mode Involving γ′-Carbon of α-Substituted Allenoate

A phosphine-catalyzed [4 + 2] cycloaddition of cyclic α-substituted allenoates with sulfamate-derived cyclic imines has been reported. Using dibenzylphenylphosphine as the nucleophilic catalyst, the reaction worked efficiently to yield various fused multicyclic heterocyclic compounds in high yields with excellent diastereoselectivities. It undergoes a new reaction mode involving γ′-carbon of α-substituted allenoate.