347-54-6

Basic information

• Product Name: 5-Fluorosalicylaldehyde
• Synonyms: 5-FLUORO-2-HYDROXYBENZALDEHYDE;5-FLUOROSALICYLALDEHYDE;5-Fluoro-2-Hydroxybenzaldehyde 5-Fluoro Salicylic Aldehyde;5-Fluoro-2-hydroxybenzaldehyde,97%;5-FluoroSalicylicAldehyde;5-FLUORO-2-HYDROXYBENZALDEHYDE, 98+%;5-Fluorosalicylaldehyde, 98+%;5-Fluorosalicylaldehyde, 4-Fluoro-2-formylphenol
• CAS NO: 347-54-6
• Molecular Formula: C₇H₅FO₂
• Molecular Weight: 140.11
• EINECS: 1533716-785-6
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde
• Mol File: 347-54-6.mol
• Article Data: 27

Chemical Properties

• Melting Point: 82-85 °C(lit.)
• Boiling Point: 56 °C / 1mmHg
• Flash Point: 79.2 °C
• Appearance: /Powder or Flakes
• Density: 1.35 g/cm³
• Vapor Pressure: 3.3mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.18±0.18(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 5-Fluorosalicylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluorosalicylaldehyde(347-54-6)
• EPA Substance Registry System: 5-Fluorosalicylaldehyde(347-54-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 347-54-6(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

5-Fluorosalicylaldehyde may be used to synthesize:managanese (III) complex [MnLa(μ1,3-N3)]n [H2La = N,N′-bis(5-fluorosalicylidene)-1,2-diaminoethane]enantiopure 4-amino-6-fluoro-3-(hydroxymethyl)chromanes4,4′-difluoro-2,2′-[(hydrazine-1,2-diylidene)bis(methanylylidene)]-diphenolN,N′-bis(5-fluoro-2-hydroxybenzylidene)ethylenediamineN,N′-(2-hydroxypropane-1,3-diyl)-bis(salicylaldimine (H2L)

General Description

5-Fluorosalicylaldehyde can be synthesized from 4-fluorophenol.

InChI:InChI=1/C7H6F3NS/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4H,11H2

Upstream product

• 50-00-0 formaldehyd 
• 371-41-5 4-Fluorophenol 
• 452-72-2 4-fluoro-2-methylphenol 
• 91407-40-8 5-fluoro-2-hydroxybenzaldehyde oxime 
• 76-05-1 trifluoroacetic acid 
• 19415-51-1 5-fluoro-2-methoxybenzaldehyde 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 1998-90-9 2-acetoxy-5-fluoro benzyl acetate 
• 67-66-3 chloroform 
• 2357-33-7 5-fluoro-2-hydroxy-benzyl alcohol 
• 496-69-5 2-bromo-4-fluoro-phenol 
• 68-12-2 N,N-dimethyl-formamide 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 179728-59-7 2-(2,2-diethoxyethoxy)-5-fluorobenzaldehyde 
• 212909-78-9 2-propenyl-4-fluorophenol 
• 312314-37-7 2-(benzyloxy)-5-fluorobenzaldehyde 
• 863288-39-5 methyl (E)-3-(5-fluoro-2-hydroxyphenyl)acrylate 
• 949449-09-6 3-(5-fluoro-2-hydroxyphenyl)acrylic acid ethyl ester 
• 946134-86-7 5-fluoro-2-[4-(trifluoromethyl)benzyloxy]benzaldehyde 
• 946134-94-7 C₁₅H₁₁ClF₄O 
• 946134-98-1 C₂₇H₂₄F₄O₄S 
• 946134-90-3 C₁₅H₁₂F₄O₂ 
• 877263-50-8 C₁₁H₁₅FO₂Si 
• 89197-62-6 5-fluorobenzofuran-2-carboxylic acid 
• 1188543-73-8 (4R)-2-(5-fluoro-2-hydroxyphenyl)thiazolidine-4-carboxylic acid 
• 1181081-45-7 (3R)-1-[(5Z)-5-[(5-fluoro-2-hydroxyphenyl)methylidene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-N,N-dimethylpyrrolidin-3-aminium chloride 
• 1162642-05-8 (4R)-4-(5-fluoro-2-hydroxy-phenyl)-4-hydroxy-butan-2-one 

Relevant articles and documents

Benzimidazole Based ‘Turn on’ Fluorescent Chemodosimeter for Zinc Ions in Mixed Aqueous Medium

Benzimidazole based compound 3 is designed and synthesized. The compound 3 is evaluated as fluorogenic sensor for metal ions in mixed aqueous solutions. Among all the metal ions tested, the compound 3 selectively senses Zn2+ ions. The imine bond of 3 gets cleaved by Zn2+ ions. Thus, 3 behave as ‘turn on’ fluorescent chemodosimeter for Zn2+ ions with limit of detction in micromolar range. Furthurmore, we demonstated that 3 can detect Zn2+ ions in cells of Allium cepa. [Figure not available: see fulltext.]

Synthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light

Synthesis of new Schiff's base Zn-complexes for photo-oxidation of methyl arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of methyl arenes which are converted into its respective aldehydes with moderate yields under visible light irradiation. The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the methyl groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of methyl arenes is reported under visible-light-driven conditions.

Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines

Phosphine-catalyzed [3+2] annulation of β-sulfonamido-substituted enones and sulfamate-derived cyclic imines has been developed, giving a series of imidazoline derivatives in moderate to excellent yields with good to excellent diastereoselectivities. A scale-up reaction worked well under mild reaction conditions. A possible mechanism was proposed on the basis of the results obtained.