212965-12-3Relevant academic research and scientific papers
Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors
Woods, Keith W.,McCroskey, Richard W.,Michaelides, Michael R.,Wada, Carol K.,Hulkower, Keren I.,Bell, Randy L.
, p. 1325 - 1328 (2007/10/03)
The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.
Heterocyclic compounds as COX-2 inhibitors
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, (2008/06/13)
The present invention relates to COX-2 inhibitors of the formula: STR1 wherein, A=halogen, C1 -C6 alkyl, SR1 or OR1 ; B=O, or H,H; X=Br or Cl; L=5-,6- or 7-membered heteroatom containing rings and is preferrably a 5-membered heteroaromatics such as thiazole, oxazole, imidazole, or oxadiazole; n=1-6, wherein the (C) is optionally branched; R=optionally substituted aryl wherein aryl is selected from phenyl, pyridyl, naphthyl, benzothienyl, or quinoxolyl, alkyl, carboxyl, esters, amino, amide, or urea; and R1 =alkyl. The compounds are useful as research tools and could be useful as potential therapeutic agents in the inhibition of the PGHS-2 isozyme and in the treatment of inflammation in mammals including humans or other conditions associated with the production of prostaglandins.
