212966-50-2

Upstream product

• 934962-72-8 1-aza-spiro[4.4]non-8-en-7-one 
• 157138-04-0 tert-butyl 2-formyl-2-acetonylpyrrolidine-1-carboxylate 
• 157138-05-1 tert-butyl 7-oxo-1-azaspiro<4.4>non-8-ene-1-carboxylate 
• 157138-02-8 tert-butyl 2-hydroxymethyl-2-(prop-2-enyl)pyrrolidine-1-carboxylate 
• 157138-03-9 tert-butyl 2-formyl-2-(prop-2-enyl)pyrrolidine-1-carboxylate 
• 112348-45-5 1-tert-butyl 2-methyl 2-(prop-2-en-1-yl)pyrrolidine-1,2-dicarboxylate 

Relevant academic research and scientific papers

Approaches to the cephalotaxine skeleton using an intramolecular heck reaction

1-[2-(o-Iodophenyl)acetyl]-2-(prop-2-enyl)-2-vinylpyrrolidine (17), upon treatment with palladium(II) acetate [Pd(OAc)2] in the presence of tripheoylphosphine and triethylamine in refluxing acetonitrile, gave the monocylization product 20 as the major product along with a small amount of the tandem cyclization product 21. On the other hand, treatment of the 1-[2- (o-iodophenyl)aeetyl]-1-azaspiro[4.4]non-8-en-7-one (25) with Pd(OAc)2, 1,3- bis-(diphenylphosphino)propane, tributylphosphine, and silver carbonate in boiling N,N-dimethylformamide afforded the cyclized product 27 in 51% yield.