934962-72-8

Upstream product

• 157138-05-1 tert-butyl 7-oxo-1-azaspiro<4.4>non-8-ene-1-carboxylate 
• 157138-04-0 tert-butyl 2-formyl-2-acetonylpyrrolidine-1-carboxylate 
• 157138-02-8 tert-butyl 2-hydroxymethyl-2-(prop-2-enyl)pyrrolidine-1-carboxylate 
• 157138-03-9 tert-butyl 2-formyl-2-(prop-2-enyl)pyrrolidine-1-carboxylate 
• 112348-45-5 1-tert-butyl 2-methyl 2-(prop-2-en-1-yl)pyrrolidine-1,2-dicarboxylate 

Downstream Products

• 212966-47-7 1-(o-iodobenzyl)-1-azaspiro<4.4>non-8-en-7-one 
• 934962-78-4 C₁₈H₂₁NO₄ 
• 212966-50-2 1-<2-(o-iodobenzyl)acetyl>-1-azaspiro<4.4>non-8-en-7-one 

Relevant academic research and scientific papers

Novel formal synthesis of cephalotaxine via a facile friedel - Crafts cyclization

Figure presented A novel formal synthesis of cephalotaxine (CET), the parent structure of the antileukemia Cephalotaxus alkaloids, was achieved via a facile Friedel-Crafts cyclization of the amino (or amido) spiro-cyclopentenone precursor (A) mediated by

Approaches to the cephalotaxine skeleton using an intramolecular heck reaction

1-[2-(o-Iodophenyl)acetyl]-2-(prop-2-enyl)-2-vinylpyrrolidine (17), upon treatment with palladium(II) acetate [Pd(OAc)2] in the presence of tripheoylphosphine and triethylamine in refluxing acetonitrile, gave the monocylization product 20 as the major product along with a small amount of the tandem cyclization product 21. On the other hand, treatment of the 1-[2- (o-iodophenyl)aeetyl]-1-azaspiro[4.4]non-8-en-7-one (25) with Pd(OAc)2, 1,3- bis-(diphenylphosphino)propane, tributylphosphine, and silver carbonate in boiling N,N-dimethylformamide afforded the cyclized product 27 in 51% yield.