212970-75-7Relevant academic research and scientific papers
Synthesis and properties of a novel bridged nucleic acid with a P3′ → N5′ phosphoramidate linkage, 5′-amino-2′,4′-BNA
Obika, Satoshi,Nakagawa, Osamu,Hiroto, Akiko,Hari, Yoshiyuki,Imanishi, Takeshi
, p. 2202 - 2203 (2003)
5′-Amino-2′,4′-BNA, a novel analogue of BNA series compounds, was successfully synthesized, and its incorporated oligonucleotides showed potent duplex- and triplex-forming ability and resistance against snake venom phosphodiesterase.
Bicyclonucleoside and oligonucleotide analogue
-
, (2008/06/13)
An oligo- or polynucleotide analogue having one or more structures of the general formula where B is a pyrimidine or purine nucleic acid base, or an analogue thereof, is disclosed. The use of this analogue provides an oligonucleotide analogue antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized.
Novel bicyclonucleoside and oligonucleotide analogue
-
, (2008/06/13)
An oligo- or polynucleotide analogue having one or more structures of the general formula where B is a pyrimidine or purine nucleic acid base, or an analogue thereof, is disclosed. The use of this analogue provides an oligonucleotide analogue antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized.
Bicyclonucleoside and oligonucleotide analogues
-
, (2008/06/13)
An oligo- or polynucleotide analogue having one or more structures of the general formula where B is a pyrimidine or purine nucleic acid base, or an analogue thereof, is disclosed. The use of this analogue provides an oligonucleotide analogue antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized.
