213014-28-9Relevant academic research and scientific papers
α-alkyl-α-amino-β-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1
Becker, Daniel P,DeCrescenzo, Gary,Freskos, John,Getman, Daniel P,Hockerman, Susan L,Li, Madeleine,Mehta, Pramod,Munie, Grace E,Swearingen, Craig
, p. 2723 - 2725 (2007/10/03)
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from >10 to >1000. Selected comp
