38778-05-1

Basic information

• Product Name: 4-PHENOXYTHIOPHENOL
• Synonyms: 4-PHENOXYTHIOPHENOL;4-PHENOXY-BENZENETHIOL
• CAS NO: 38778-05-1
• Molecular Formula: C₁₂H₁₀OS
• Molecular Weight: 202.27
• Mol File: 38778-05-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 128°C/0.1mm
• Flash Point: 140.3 °C
• Appearance: /
• Density: 1.171g/cm³
• Vapor Pressure: 0.00124mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 4-PHENOXYTHIOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENOXYTHIOPHENOL(38778-05-1)
• EPA Substance Registry System: 4-PHENOXYTHIOPHENOL(38778-05-1)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 38778-05-1(Hazardous Substances Data)

Usage

General Description

4-Phenoxythiophenol is an organic compound with the chemical formula C10H9OS. It is a white to light brown solid that is insoluble in water but soluble in organic solvents. 4-Phenoxythiophenol is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also commonly used as a reagent in organic chemistry reactions, particularly in the formation of carbon-sulfur bonds. Additionally, 4-Phenoxythiophenol exhibits antioxidant properties, which makes it potentially useful in the development of antioxidant products for various applications.

InChI:InChI=1/C12H10OS/c14-12-8-6-11(7-9-12)13-10-4-2-1-3-5-10/h1-9,14H

Upstream product

• 1623-92-3 4-phenoxyphenylsulfonyl chloride 
• 101-55-3 4-Bromodiphenyl ether 
• 51289-12-4 4-(4-bromophenoxy)thiophenol 
• 2974-94-9 4-phenoxyiodobenzene 
• 139-59-3 4-phenoxyanilin 
• 831-82-3 4-Phenoxyphenol 
• 198062-93-0 S-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate 
• 198062-96-3 O-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate 
• 101-84-8 diphenylether 

Downstream Products

• 88590-36-7 1-(4-nitro-phenylsulfanyl)-4-phenoxy-benzene 
• 202666-42-0 3-(4-phenoxy-phenylsulfanyl)-propan-1-ol 
• 292605-10-8 5-(4-phenoxyphenylsulfanyl)-1-pentene 
• 3159-49-7 3-(4-phenoxyphenylsulfanyl)-1-propene 
• 292605-12-0 2-(4-phenoxyphenylsulfonyl)ethyloxirane 
• 292605-13-1 3-(4-phenoxyphenylsulfonyl)propyloxirane 
• 1009373-07-2 methyl (2R)-2-[N-(t-butoxycarbonyl)amino]-3-(4-phenoxy)thiophenoxypropionate 
• 198062-93-0 S-(4-phenoxyphenyl)-N,N-dimethylthiocarbamate 
• 527758-72-1 2-(4-Phenoxyphenylsulphonyl)methyl-5-succinimidopentanoic acid 

Relevant articles and documents

Discovery of 3,5-Dimethyl-4-Sulfonyl-1 H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability

Myeloid cell leukemia 1 (Mcl-1) protein is a key negative regulator of apoptosis, and developing Mcl-1 inhibitors has been an attractive strategy for cancer therapy. Herein, we describe the rational design, synthesis, and structure-activity relationship study of 3,5-dimethyl-4-sulfonyl-1H-pyrrole-based compounds as Mcl-1 inhibitors. Stepwise optimizations of hit compound 11 with primary Mcl-1 inhibition (52%@30 μM) led to the discovery of the most potent compound 40 with high affinity (Kd = 0.23 nM) and superior selectivity over other Bcl-2 family proteins (>40,000 folds). Mechanistic studies revealed that 40 could activate the apoptosis signal pathway in an Mcl-1-dependent manner. 40 exhibited favorable physicochemical properties and pharmacokinetic profiles (F% = 41.3%). Furthermore, oral administration of 40 was well tolerated to effectively inhibit tumor growth (T/C = 37.3%) in MV4-11 xenograft models. Collectively, these findings implicate that compound 40 is a promising antitumor agent that deserves further preclinical evaluations.

ISOTHIOCYANATE COMPOUND AND APPLICATION THEREOF

The present invention provides an isothiocyanate compound and its application. The compound is an aryl-substituted isothiocyanate compound that has a structure of the general formula I. The isothiocyanate compound of the present invention has very good solubility in water, far better inhibitory activity for XPO1 protein than other non-aryl substituted congeneric compounds, little side effects, and good biological safety and bioavailability, and is quite suitable for clinical application. Therefore, the isothiocyanate compound would have tremendous potential market space and economic benefits.

A Convenient Synthesis of a Selective Gelatinase Inhibitor as an Antimetastatic Agent

Compound 1, 2-(4-phenoxyphenylsulfonylmethyl)thiirane, is a potent and selective inhibitor for human gelatinases (J. Am. Chem. Soc. 2000, 122, 6799-6800), enzymes implicated in a number of diseases, including cancer. This compound is showing excellent pro