213025-72-0

Usage

Uses

Used in Organic Synthesis:
(RS)-1-benzyl-2-oxo-3-(tert-butoxycarbonylamino)-azepine is utilized as a building block in organic synthesis, allowing for the creation of a diverse range of compounds. Its unique structure and reactivity make it a valuable component in the development of novel chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (RS)-1-benzyl-2-oxo-3-(tert-butoxycarbonylamino)-azepine serves as a key intermediate for the synthesis of new drugs and pharmaceuticals. Its potential applications in drug development are attributed to its distinctive structural features and the possibility of further chemical modifications.
Overall, (RS)-1-benzyl-2-oxo-3-(tert-butoxycarbonylamino)-azepine is a versatile chemical compound with significant applications in both organic synthesis and pharmaceutical research, showcasing its importance in the development of new compounds and potential therapeutic agents.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 29426-64-0 (R)-α-amino-ε-caprolactam hydrochloride 
• 100-39-0 benzyl bromide 
• 179686-45-4 3-(S)-tert-butoxycarbonylamino-4,5,6,7-tetrahydroazepin-2-one 

Downstream Products

• 202819-52-1 (RS)-3-amino-2-oxo-1-benzyl-azepine 

Relevant academic research and scientific papers

Substituted Pyrrololactams via Ring Expansion of Spiro-2H-pyrroles from Intermolecular Alkyne-Isocyanide Click Reactions

The facile synthesis of 6- to 8-membered pyrrololactams has been developed using a ring expansion of spiro-2H-pyrroles, the products of intermolecular alkyne-isocyanide click reactions. The key to successful ring expansion of spiro-2H-pyrroles to pyrrololactams is the enforced orbital overlap between the internal alkene and the amide carbonyl group through the conformationally locked bicyclic structures. The newly disclosed α-isocyano lactams, substrates for click reactions, should find their utility in the synthesis of pharmaceutically important heterocyclic compounds.

Facile synthesis of versatile functionalized amino caprolactams using RCM reactions of α-amino acrylamide

We report an efficient synthetic methodology allowing access to functionalized α-amino caprolactams using ring-closing metathesis (RCM). A very high tolerance of α-amino acrylamide RCM precursors toward functional groups is demonstrated. The synthetic pat

Parallel liquid synthesis of N,N′-disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors

A rapid structure-activity study was performed by parallel liquid synthesis on N,N′-disubstitution of 3-amino azepin-2-one to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities. The activities of the selected compounds were validated in vivo, and compounds 41a and 44a presented significant antitumour activity.